Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1995-11-14
1997-09-09
Conrad, Joseph
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
558411, 558412, 558414, 562621, A61K 3119, C07C25500, C07C25908
Patent
active
056657773
ABSTRACT:
Compounds of formula ##STR1## or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF.alpha. secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF.alpha. secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF.alpha. secretion.
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patent: 3755603 (1973-08-01), Harrison et al.
patent: 4599361 (1986-07-01), Dickens et al.
patent: 5036157 (1991-07-01), Kneen et al.
Testa, M.F., and Shapiro, S.L., J. Med. Chem.,1966, 9 (3), 449.
Carrera, Jr. George M.
Davidsen Steven K.
Fesik Stephen W.
Florjancic Alan
Holms James H.
Abbott Laboratories
Browder Monte R.
Conrad Joseph
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