Biomarkers and assays for myocardial infarction

Details Biomarkers and assays for myocardial infarction Biomarkers and assays for myocardial infarction

2010-10-18

2011-10-04

Cook, Lisa (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007100, C436S001000, C436S501000, C436S518000, C424S009100, C424S520000, C422S050000, C530S300000, C530S350000

Reexamination Certificate

active

08030011

ABSTRACT:
Presented herein are novel blood plasma/serum biomarkers related to cardiovascular disease. These newly identified biomarkers create the basis for multiple (single) assays using traditional bioassay technologies and when used in combination yield exceptional clinical sensitivity and specificity in the determination of myocardial infarction (MI). A multiplexed, mass spectrometric immunoassay (MSIA) able to simultaneously assay for the new
ovel biomarkers as well other MI markers is also presented. Means and methods for evaluating data generated using multiple biomarkers in order to validate findings and further the use of the multiplexed MI assay in clinical, diagnostic and therapeutic uses is also included.

REFERENCES:
Patel et al. (Biochemical Journal, 1996, vol. 318, No. 3, pp. 1041-1049).
Bausserman et al. (Journal of Experimental Medicine, 1980, vol. 152, No. 3, pp. 641-656).

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