Biological and chemical method for hydroxylating 4-substituted b

Details Biological and chemical method for hydroxylating 4-substituted b Biological and chemical method for hydroxylating 4-substituted b

1989-12-20

1991-01-01

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing nitrogen-containing organic compound

435156, 435170, 435829, 435877, C12P 702, C12P 104, C12R 105, C12R 140

Patent

active

049817930

ABSTRACT:
A method is provided for converting 4-substituted biphenyls, such as 4-hydroxybiphenyl, to the corresponding 3,4'-dihydroxybiphenyl utilizing mutant strains of Alcaligenes eutrophus or Pseudomonas putida. Hydroxylation of the unsubstituted biphenyl ring to the corresponding (1S-cis)-3-(4-hydroxyphenyl)-3,5-cyclohexadiene-1,2-diol and its conversion to the corresponding triacetate, followed by treatment in base to form 3,4'-dihydroxybiphenyl is also provided.

REFERENCES:
patent: 4670581 (1987-06-01), Tanigaki
Furukawa, K. et al., "Gene Manipulation of Catabolic Activities for Production of Intermediates of Various Biphenyl Compounds," Appl. Microbiol. Biotechnology 29, pp. 363-369, (1988).
D. T. Gibson, J. R. Koch and R. E. Kallio-Oxidative Degradation of aromatic Hydrocarbons by Microorganisms, I. Enzymatic Formation of Catechol from Benzene-Biochemistry 5, 1445 (1966) pp. 2653-2662.
B. A. Finette, V. Subramanian and D. T. Gibson-Isolation and Characterization of Pseudomonas putida PpFl Mutants Defective in the Toluene Dioxygenase Enzyme System-Journal of Bacteriology, Dec. 1984 pp. 1003-1009.
L. M. Nadim, et al, and D. L. Bedard, et al-Bacterial Oxidation of Polychlorinated Biphenyls-pp. 395-402, 1987.

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