Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Processes of preparing a desired or intentional composition...
Patent
1985-05-30
1986-09-16
Griffin, Ronald W.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Processes of preparing a desired or intentional composition...
424 27, 128127, 1283355, 435 1, 523115, 604265, 604285, 8 9411, A61K 31625
Patent
active
046123377
ABSTRACT:
An infection-resistant polymeric material, such as polytetrafluoroethylene, for use on or within a human or animal body, for example, in the form of a vascular graft, can be prepared by an improved method which comprises the following sequence of steps: (a) soaking a polymeric material with a solution of an antimicrobial agent, such as sodium sulfadiazine, oxacillin dissolved in an organic solvent therefor, such as an ethanol/chloroform mixture, (b) soaking the polymeric material with an organic solvent, such as ethanol, for a metal salt; and (c) resoaking the polymeric material with the solution of the antimicrobial agent dissolved in the organic solvent therefor. The polymeric material is dried after each soaking step. Preferably, in the intermediate soaking step (b) the organic solvent contains a metal salt, such as silver nitrate, dissolved therein, so as to form in situ the metal salt of the antimicrobial agent, such as silver sulfadiazine.
REFERENCES:
patent: 4049802 (1977-09-01), Fox
patent: 4271070 (1981-06-01), Miyata et al.
patent: 4353996 (1982-10-01), Marconi et al.
patent: 4401712 (1983-08-01), Morrison
patent: 4404197 (1983-09-01), Fox et al.
patent: 4446124 (1984-05-01), Fox et al.
patent: 4455146 (1984-06-01), Noda et al.
patent: 4462981 (1984-07-01), Smith
patent: 4563485 (1986-01-01), Fox et al.
patent: 4563489 (1986-01-01), Urist
"Vascular Prosthetic Infection", Bennion et al., Infections in Surgery, Sep. 1982, pp. 45-55.
"Control of Burn Wound Infections by Pefloxacin and its Silver Derivative", Modak et al., Burns, 10, No. 3, pp. 170-178.
"Topical Therapy and the Development of Silver Sulfadiazine", Fox, Jr., Surgery, Gyn & Ob, 157, 82-88, Jul. 1983.
"Virulence of Pseudomonas Infection in Burned Rats and Mice", Fox et al., Arch Surg., 101, pp. 508-512, Oct. 1970.
"Crystal Structure of 2-Sulfanilamidopyrimidinesilver(1)", Baenziger, et al., Inorganic Chemistry, 15, No. 8, pp. 1807-1809, (1976).
"Silver Treated Graft Materials for Coverage of Infected Burn Wounds", Fox et al., Ann. Chir. Plast., 1979, 24, No. 3, pp. 265-267.
"Sulfadiazine Silver-Resistant Pseudomonas in Burns", Modak et al., Arch Surg., 116, 854-857, Jul. 1981.
"Antibiotic Bonding to Polytetrafluoroethylene with Tridodecylmethylammonium Chloride", Harvey et al., Surgery, Sep. 1982, pp. 504-512.
Fox, Jr. Charles L.
Modak Shanta M.
Griffin Ronald W.
The Trustees of Columbia University in the City of New York
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