Biodegradable poly(β-amino esters) and uses thereof

Details Biodegradable poly(β-amino esters) and uses thereof Biodegradable poly(β-amino esters) and uses thereof

2003-05-28

2008-09-23

Hartley, Michael G. (Department: 1618)

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Monomer contains oxygen

C528S288000, C528S362000, C564S078000

Reexamination Certificate

active

07427394

ABSTRACT:
Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. A system for preparing and screening polymers in parallel using semi-automated robotic fluid delivery systems is also provided.

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