Biodegradable particulate vector for transporting molecules havi

Details Biodegradable particulate vector for transporting molecules havi Biodegradable particulate vector for transporting molecules havi

1994-05-16

1998-04-07

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an organic...

435134, 435178, 435181, 424 941, 514 2, 530402, 530813, 530814, C12N 1112, C12N 1110, A61K 3843, C07K 1712

Patent

active

057363714

ABSTRACT:
A biodegradable particulate vector for transporting biologically active molecules is prepared containing a nucleus for containing a biologically active molecule, a first layer of fatty acid compounds covalently bonded to the nucleus and a second layer of phospholipids hydrophobically bonded to the first layer. The nucleus is between 10 nm and 10 .mu.m in size and is formed of a cross-linked polysaccharide or oligosaccharide matrix onto which ionic ligands are uniformly grafted. The cross-linked polysaccharide may be dextran, cellulose or starch cross-linked with epichlorohydrin. The ligand may be an acidic compound selected from succinic acid, phosphoric acid, citric acid, glycine, alanine, glutamic acid and aspartic acid, or a basic compound such as choline, hydroxycholine, 2-(dimethylamino)ethanol or 2-(dimethylamino)ethylamine fastened onto the matrix via the acidic compound. The polysaccharide or oligosaccharide may be co-cross-linked with a protein such as keratin/collagen or elastase. The vector may be prepared by reacting succinic acid monochloride in aqueous solution with a cross-linked polysaccharide or oligosaccharide matrix to graft succinic acid onto the matrix to form the nucleus, grinding the nucleus to a size between 10 nm and 10 .mu.m, drying the ground nucleus, coupling fatty acid compounds to the nucleus to form a first layer and hydrophobically bonding phospholipids to the first layer to form a second layer. The succinic acid monochloride is preferably prepared by reacting succinic acid dichloride with free succinic acid to form pure crystalline succinic acid monochloride.

REFERENCES:
patent: 4206286 (1980-06-01), Keyes
patent: 4352883 (1982-10-01), Lim
patent: 5080833 (1992-01-01), Ishimori
patent: 5151264 (1992-09-01), Samain et al.
patent: 5206159 (1993-04-01), Samain et al.
patent: 5217715 (1993-06-01), Krivan et al.

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