Bioconversion products of 27-hydroxy avermectin

Details Bioconversion products of 27-hydroxy avermectin Bioconversion products of 27-hydroxy avermectin

1994-05-20

1995-12-26

Fox, David T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 435 76, 435105, 435119, C07H 1708, A61K 3170

Patent

active

054789290

ABSTRACT:
There are disclosed novel compounds which are derived from 22,23-dihydro avermectin B1 aglycone. The compounds are both isomers of the 27-hydroxy adduct of the substrate avermectin compound that have been glycosylated at the 4" position to yield 4"-O-glucosyl 27-OH avermectin compounds. The compounds and the intermediates used to make them are highly potent antiparasitic, insecticidal and anthelmintic avermectin agents.

REFERENCES:
patent: 4199569 (1980-04-01), Chabala et al.
patent: 4206205 (1980-06-01), Mrozik et al.
patent: 4310519 (1982-01-01), Albers-Schonberg et al.
patent: 4666937 (1987-05-01), Goegelman et al.
patent: 4766112 (1988-08-01), Goegelman et al.
patent: 5070015 (1991-12-01), Petuch et al.
patent: 5124258 (1992-06-01), Arison et al.
patent: 5140042 (1992-08-01), Arison et al.
patent: 5188944 (1993-02-01), Omstead et al.
patent: 5192671 (1993-03-01), Arison et al.
patent: 5250422 (1993-10-01), Petuch et al.
J. C. Chabala, et al., J. Med. Chem., 1980, 23 pp. 1134-1136.
H. Mrozik, et al., J. Med. Chem., 1982, 47, pp. 489-492.
B. H. Arison et al., J. Antibiotics, 46, No. 6, pp. 1016-1019 (1993).
Chemical Abstracts, 121, AB No. 103765.

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