Diagnosis and treatment of AIDS onset

Details Diagnosis and treatment of AIDS onset Diagnosis and treatment of AIDS onset

1994-10-06

1999-04-06

Smith, Lynette F.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 71, C12P 170, G01N 3353, G01N 33567

Patent

active

058916237

ABSTRACT:
The invention provides assays for the presence or absence of CD4+ T cell subpopulations carrying particular V.beta. components of the T cell receptor (TCR-V.beta.) in persons infected with HIV, including amplification of mRNA from T cells with primers specific to each TCR-V.beta. to detect the presence or absence of each TCR-V.beta. in a sample and primers for use in such amplification assays are disclosed. The invention also provides assays of antibody-containing fluids of a person infected with HIV to determine the immunodeficiency where the fluid is suspected to contain an antibody having a paratope specific to an epitope on a TCR-V.beta.. The invention also provides a binding agent specific to a paratope where the paratope is specific to an epitope on a TCR-V.beta.. The invention also provides a method of assay of the fluids of a person infected with HIV to determine the immunodeficiency of the person which utilizes a binding agent specific to complexes containing anti-TCR-V.beta. antibody bound to TCR-V.beta.. The invention also provides a method of treatment of a person infected with HIV to attenuate or avert immunodeficiency which utilize a binding agent that is homologous with an epitope on TCR-V.beta.. The invention also provides a method of treatment of a person infected with HIV to attenuate or avert immunodeficiency which involves removing an antibody capable of binding to an epitope on TCR-V.beta. from the blood of a person infected with HIV. Finally, the invention provides a method of vaccination of a person infected or at risk for infection with HIV which raises antiidiotypic antibodies specific to free antibodies containing a paratope specific to an epitope on a TCR-V.beta..

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