Stock material or miscellaneous articles – Composite – Of epoxy ether
Reexamination Certificate
2000-12-29
2002-10-22
Dawson, Robert (Department: 1712)
Stock material or miscellaneous articles
Composite
Of epoxy ether
C524S009000, C524S010000, C524S014000, C524S021000, C623S002100
Reexamination Certificate
active
06468660
ABSTRACT:
BACKGROUND OF THE INVENTION
The invention relates to compositions suitable for use as adhesives, especially for medical products. This invention also relates to medical devices that include portions bonded together by the adhesives.
Adhesives can be used in the medical field in a variety of ways. Medical adhesives can be used, for example, in manufacturing and/or implantation of medical devices. In surgical settings, medical adhesives provide an alternative to sutures, staples and the like for closing wounds in soft tissue. Certain tissues, such as nerves and particular vital organs, are too delicate for suturing or stapling, so the use of medical adhesives may be a viable repair option. In manufacturing settings, medical adhesives can be used to adhere one or more components of a medical device together.
Generally, the use of an adhesive for the manufacturing and/or implantation of medical devices or to repair wounds in soft tissue can be desirable due to potential sealing properties and uniform stress distribution. Adhesives provide a means for attaching substrates in the medical devices. The use of an adhesive may form an adhesive bond over the length of an attachment site. Adhesives tend to distribute the stress exerted on the attachment site over the length of the attachment site.
Generally, medical adhesives can be classified according to whether they include synthetic polymers, natural (biological) polymers or both. A variety of synthetic urethane based polymers have been developed as medical glues. Natural surgical adhesives generally are based on proteins. For example, fibrin glues include the protein fibrinogen. Fibrinogen is used in natural wound healing mechanisms in humans and other mammals. Synthetic adhesives have the disadvantage of being potentially toxic. On the other hand, biological
atural adhesives generally have relatively low binding (cohesive) strengths and rapid degradation times.
SUMMARY OF THE INVENTION
In a first aspect, the invention pertains to an adhesive composition including an epoxyamine and a curing agent. The epoxyamine is at a concentration of between about 25 percent by weight and about 90 percent by weight in the adhesive composition.
In a further aspect, the invention pertains to a prosthesis including a first substrate. The first substrate is associated with an adhesive composition that includes an epoxyamine. The concentration of the epoxyamine in the adhesive composition is between about 25percent by weight and about 90 percent by weight.
In another aspect, the invention pertains to method of securing a first substrate to a second substrate. The method includes contacting a first substrate including an adhesive composition with a second substrate to form an adhesive bond between the first and the second substrate. The adhesive composition includes an epoxyamine.
In a further aspect, the invention pertains to a method of manufacturing a heart valve prosthesis. The method includes associating a first valve component with an adhesive composition and adhering the first valve component with a second valve component to form an adhesive bond between the first valve component and the second valve component. The adhesive composition includes an epoxyamine.
In another aspect, the invention pertains to a prosthesis including at least two substrates. The substrates are adhered together by an adhesive bond. The adhesive bond is formed when an epoxyamine adhesive between the substrates is cured.
REFERENCES:
patent: 3278561 (1966-10-01), Gaertner
patent: 3678131 (1972-07-01), Klapprott et al.
patent: 4268656 (1981-05-01), Ray-Chaudhuri et al.
patent: 4414976 (1983-11-01), Schwarz et al.
patent: 4626310 (1986-12-01), Ritter
patent: 4650678 (1987-03-01), Fuhge et al.
patent: 4740534 (1988-04-01), Matsuda et al.
patent: 4798885 (1989-01-01), Mason et al.
patent: 4818291 (1989-04-01), Iwatsuki et al.
patent: 4841962 (1989-06-01), Berg et al.
patent: 4983392 (1991-01-01), Robinson
patent: 4985516 (1991-01-01), Sakashita et al.
patent: 4994542 (1991-02-01), Matsuda et al.
patent: 5160790 (1992-11-01), Elton
patent: 5173301 (1992-12-01), Itoh et al.
patent: 5218073 (1993-06-01), Evans
patent: 5266608 (1993-11-01), Katz et al.
patent: 5280069 (1994-01-01), Dobinson et al.
patent: 5292333 (1994-03-01), Johnson
patent: 5385606 (1995-01-01), Kowanko
patent: 5486547 (1996-01-01), Matsuda et al.
patent: 5512527 (1996-04-01), Ritter
patent: 5583114 (1996-12-01), Barrows et al.
patent: 5591820 (1997-01-01), Kydonieus et al.
patent: 5653730 (1997-08-01), Hammerslag
patent: 5855620 (1999-01-01), Bishopric et al.
patent: 6379379 (2002-04-01), Wang
patent: 6379615 (2002-04-01), Ogle
patent: 6391538 (2002-05-01), Vyavahare et al.
patent: 198 49 589 C 1 (2000-06-01), None
patent: 0 199 247 (1986-10-01), None
patent: 0 332 405 (1989-09-01), None
patent: 0 747 066 (1996-12-01), None
patent: WO 92/09301 (1992-06-01), None
patent: WO 92/09309 (1992-06-01), None
patent: WO 94/01508 (1994-01-01), None
patent: WO 97/32615 (1997-09-01), None
patent: WO 98/59011 (1998-12-01), None
M.J. MacPhee, “Commercial Pooled-Source Fibrin Sealant”, Surgical Adhesive and Sealants, Edited by David Sierra and Renato Saltz, pp. 13-18.
Young et al., “Fibrin Suture of Peripheral Nerves”, The Lancet, Aug. 3, 1940, pp. 126-128.
Young et al., “Nerve Regeneration”, The Lancet, Aug. 3, 1940, pp. 128-132.
Ross et al., “Some Reactions of Epichlorohydrin with Amines”, The Journal of Organic Chemistry, vol. 29, Jan.-Apr. 1964, pp. 824-826.
G. Köveker, “Clinic Application of Fibrin Glue in Cardiovascular Surgery”, Thorac. Cardiovasc. Surgeon 30, 1982, pp. 228-229.
Brands et al., “Treatment of Ruptured Kidney by Gluing with Highly Concentrated Human Fibrinogen”, Journal of Pediatric Surgery, vol. 18, No. 5, Oct. 1983, pp. 611-613.
Meyers et al., “A Fibrin Adhesive Seal for the Repair of Osteochondral Fracture Fragments”, Clinical Orthopaedics and Related Research, No. 182, Jan.-Feb. 1984, pp. 258-263.
Sugiura et al., “A New Method for Venous Interposition Grafts Using Fibrin Glue”, Microsurgery vol. 6, 1985, pp. 125-128.
Hasegawa et al., “Closure of Carotid-Cavernous Fistulae by Use of a Fibrin Adhesive System”, Surg. Neurol., 1985, vol. 24, pp. 23-26.
Keller et al., “Fixation of Osteochondral Fractures”, Acta. Orthop. Scand., vol. 56, 1985, pp. 323-326.
Kram et al., “Tracheal Repair with Fibrin Glue”, J. Thorac. Cardiovasc. Surg., 1985, vol. 90, pp. 771-775.
Bornemisza et al., “Restoration of Skin Defects with Fibrin Glue”, Acta Chirurgica Hungarica, vol. 27(4), 1986, p. 249-258.
Chezlov et al., “Production of N,N,N-Triglycidylamine”, USSR, Zh.Prikl. Khim. (Leningrad), 1990, 63(8), pp. 1877-1878, Coden: ZPKHAB; ISSN: 0044-4618, Journal written in Russian. CAN 114:121880.
Seymour S. Block, “Disinfection, Sterilization and Preservation”, Lea & Febiger, 1991, pp. 1050-1051 & 1060.
Chezlov et al., “Structure and Reactivity of Oxirane-Type Chemical Modifiers for Gelatin”, St. Petersburg, Russia, Zh. Prik Khim (St. Petersburg), 1998, vol. 71(1), pp. 149-156, Coden: ZPKHAB; ISSN: 0044-4618, Journal written in Russian. CAN 129:17075.
International Search Report (PCT/US01/49336) dated Aug. 5, 2002.
McConico Andrea L.
Ogle Matthew F.
Dardi Peter S.
Dawson Robert
Finucane Hallie A.
Keehan Christopher M.
Patterson Thuente Skaar & Christensen P.A.
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