Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1998-04-21
1999-11-30
Bawa, Raj
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424435, 424436, 424450, 514937, 514938, A61K 9107
Patent
active
059938463
ABSTRACT:
The invention relates to novel methods for making oil-in-water emulsions having mucoadhesive properties which are primarily intended for administration of biologically active compounds to mucosal surfaces. The emulsion has an aqueous continuous phase and a plurality of submicron particles having an average particle diameter of from 10 nm to 600 nm, with the particles having a hydrophobic phase of a fat or oil which forms a hydrophobic core that is surrounded by a surfactant layer. The emulsion further includes a mucoadhesive polymer which is a polymer or copolymer of acrylic acid or methacrylic acid, a poly (methyl vinyl ether/maleic anhydride) copolymer, pectin, alginic acid, hyaluronic acid, chitosan, gum tragacanth, karaya gum or carboxymethylcellulose surrounding the hydrophobic one. A biologically active compound may also be included, if desired. The hydrophobic core has less than 1% (w/w) protein, relative to the weight of the hydrophobic core, and the emulsion contains less than 5% (w/w) surfactant, relative to the weight of the hydrophobic phase.
REFERENCES:
patent: 4548922 (1985-10-01), Carey et al.
patent: 5055303 (1991-10-01), Riley, Jr.
patent: 5120710 (1992-06-01), Liedtke
patent: 5188837 (1993-02-01), Domb
Longer, M.A. and J.R. Robinson (1986). Pharmacy International, May Issue 1986, pp. 114-117.
Nagai, T. and Y. Machida (1985). Pharmacy International, Aug. 1985, pp. 196-200.
Davis, S.S. (1992) J. Pharm. Pharmacol, 44 (Suppl. 1): 186-190.
Ritschel, W. A., (1991). Meth Find Exp Clin Pharmacol 13(3): 205-220.
Amselem Shimon
Friedman Doron
Schwarz Joseph
Bawa Raj
Pharmos Corporation
LandOfFree
Bioadhesive emulsion preparations for enhanced drug delivery does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bioadhesive emulsion preparations for enhanced drug delivery, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bioadhesive emulsion preparations for enhanced drug delivery will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1668390