Bioactive coating composition and methods

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C514S056000, C523S122000, C427S002100, C427S002130, C604S057000, C623S001420

Reexamination Certificate

active

06921811

ABSTRACT:
The present invention provides a bioactive coating composition, method and devices for bodily fluid-contacting surfaces. The coating comprises a complex of Formula II: wherein R1is an C1-18alkyl or C6-32aryl group, each R2is independently selected from the group consisting of C1-18alkyl and C6-32aryl, R3is N or O, n is a number from 1 to 10, and x in a number from 1 to about 30, directly bound to a heparin-activity molecule via covalent bonding, with one or more bioactive molecules bound to the heparin-activity molecule. The bioactive molecule may be an adhesive molecule such as fibronectin, a growth factor such as basic fibroblast growth factor, or any other bioactive molecule that binds, by any mechanism, to a heparin-activity molecule

REFERENCES:
patent: 5308617 (1994-05-01), Halluin
patent: 5334379 (1994-08-01), Pillai et al.
patent: 5955588 (1999-09-01), Tsang et al.

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