Beta-secretase substrates and uses thereof

Details Beta-secretase substrates and uses thereof Beta-secretase substrates and uses thereof

2006-11-07

2006-11-07

Borin, Michael (Department: 1631)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C435S007100

Reexamination Certificate

active

07132401

ABSTRACT:
The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.

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