Beta-lactams and their production

Details Beta-lactams and their production Beta-lactams and their production

1994-02-17

1995-06-13

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20508, C07D48704

Patent

active

054244226

ABSTRACT:
A beta-lactam compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are, the same or different, each a hydrogen atom or a lower alkyl group, R.sub.3.sup.o is a lower alkyl group having a beta-configuration, R.sub.4 is a carboxyl-protecting group, X is a hydrogen atom or a protected hydroxyl group and COZ is a protected thiolcarboxyl group, which is useful as a valuable intermediate in the stereospecific production of 1-alkylcarbapenem compounds.

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Farina et al. (1989) J. Org. Chem. 54: 4962-4966.
Sowinn et al. (1988) J. Org. Chem., 53:4154-4156.
von Riccardo Scartazzini et al., (1974), Helvetica Chimica Acta (vol. 2) Fasc. 7, 1919-1924.
von Riccardo Scartazzini et al., (1973), Helvetica Chimica Acta (vol. 58, Fasc. 8), 2437-2441.
Schmitt et al. (1980) J. Org. Chem., 45(6) 1142-1145.

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