Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-05-27
1995-07-18
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514292, 540524, 546 87, C07D47104, C07D48704, A61K 3155, A61K 3144
Patent
active
054341485
ABSTRACT:
Disclosed are .beta.-carboline derivatives represented by the formula: ##STR1## wherein R.sup.1 represents hydrogen atom, a lower alkyl group, a lower alkoxy group or hydroxy group; R.sup.5 represents hydrogen atom, or R.sup.1 and R.sup.5 are bonded to represent a lower alkylenedioxy group; R.sup.2 represents hydrogen atom, a halogen atom, a lower alkoxy group or hydroxy group; R.sup.3 represents hydrogen atom, a carbamoyl lower alkyl group, a lower alkyl group, a carboxy lower alkyl group or a lower alkoxycarbonyl lower alkyl group; R.sup.4 represents hydrogen atom, a lower alkyl group, a carboxy lower alkyl group, a lower alkoxycarbonyl lower alkyl group, a lower alkanoyl group, an arylcarbonyl group, a lower alkanesulfonyl group, a lower alkoxycarbonyl group, an aralkyl group, formyl group or a di(lower alkyl)sulfamoyl group; n represents 0, 1 or 2; and the symbol * represents an asymmetric carbon atom,
or a pharmaceutically acceptable salt thereof, and a process for preparing the same.
REFERENCES:
patent: 4001263 (1977-01-01), Plattner et al.
patent: 4981847 (1991-01-01), Sato et al.
patent: 4992437 (1991-02-01), Naka et al.
Lippke et al. (1985) Journal of Pharmaceutical Sciences 74(6):676-80.
Ganong, William F., MD, "Regulation of Gastrointestinal Function," Review of Medical Physiology, 15th Ed., pp. 451-452 (1991).
Kerwin, Drugs of the Future, vol. 16, No. 12, pp. 1111-1119 (1991).
Hikota Masataka
Nagasaki Masaaki
Shikano Toshiro
Yamada Koichiro
Yura Takeshi
Rotman Alan L.
Tanabe Seiyaku Co. Ltd.
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