Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S183000, C514S247000, C514S248000, C514S277000, C514S279000, C514S280000

Reexamination Certificate

active

07125873

ABSTRACT:
The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

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patent: WO 02/02560 (2002-01-01), None
Herman et al. Clinical Pharmacology & Therapeutics 2005; 78(6):675-88 Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies.
“Novel N-substituted-2-cyanopyrrolidines as potent inhibitors of dipeptidyl peptidase IV in the treatment of non-insulin-dependent diabetes mellitus”, Exp. Opin, Ther. Patents, 10(12), pp. 1937-1942 (2000).
Ashworth, et al., “2-Cyanopyrrolidides as Potent, Stable Inhibitors of Dipeptidyl Peptidase IV”, Bioorg. Med. Chem. Lett., vol. 6, No. 10, pp. 1163-1166, (1996).
Ashworth, et al., “4-Cyanothiazolidides as Very Potent, Stable Inhibitors of Dipeptidyl Peptidase IV”, Bioorg. Med. Chem. Lett., vol. 6, No. 22, pp. 2745-2748, (1996).
Deacon, et al., “Dipeptidyl peptidase IV inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective”, Biochem. Biophys. Res. Commun. vol. 294, pp. 1-4 (2002).
Stoeckel-Maschek A., et al: “Potent Inhibitors of Dipeptidyl Peptidase IV and Their Mechanisms of Inhibition” Advances in Experimental Medicine and Biology, vol. 477, pp. 117-123, (2000).

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