Beta-amino acid derivatives as integrin receptor antagonists

Details Beta-amino acid derivatives as integrin receptor antagonists Beta-amino acid derivatives as integrin receptor antagonists

2006-08-15

2006-08-15

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C560S002000, C560S045000

Reexamination Certificate

active

07091242

ABSTRACT:
The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseases.

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Saksena et al., 2002, CAS: 139:381756.
Bergel, F. et al., “Synthesis of Beta-(p-bis(2-chloroethyl)aminophenyl)-DL-Beta-alanine, a new amino acid derivative with tumour-inhibiting properties”, Chem & Ind. pp. 1487 (1959).
Aberhart, D. et al., “Synthesis of Geometrical Isomers of Beta-Arylamidoacrylic Esters,”. J. Org. Chem. 46, 3749-3751 (1981).
Johnson, J.M., “Synthesis of Beta(m-bis(2-Chloroethyl)aminophenyl)-DL-Beta-alanine”, Chem & Ind., 966-967, (1960).

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