Benzoxazole derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514218, 544361, 544368, 540575, A61K 31495, A61K 3155, C07D40100, C07D41900

Patent

active

056312571

ABSTRACT:
A benzoxazole derivative of the formula (1) or (2) which has an alicyclic diamine group at the 2-position: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, X.sup.-, m and n are defined herein. The compound shows excellent 5-HT.sub.3 receptor antagonism and is useful as an antiemetic agent, a peristalsis controlling agent, an analgesic agent, an antianxiety agent and a schizophrenia treating agent.

REFERENCES:
patent: 4877878 (1989-10-01), Kampe et al.
Monge et al. CA 120:323489 (1994).
Nakao et al. CA 116:194290 (1992).
Ogawa et al. CA 114:102062 (1990).
Ray et al. CA 112:21013 (1989).
Verderame. CA 69:106666 (1968).
Tomcufcik et al. CA 67:90839 (1967).

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