Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-05-23
2006-05-23
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S048000, C544S051000, C544S052000
Reexamination Certificate
active
07049312
ABSTRACT:
Q is —N=or CR2X is S, O or NOR3Y is —O—, —S—, —SO— or —SO2—R and R1are each, independently, H, a substituted or unsubstituted aliphatic, aromatic, heteroaromatic or aralkyl groupR2is H or a substituentR3is H, or —C(O)R4R4is a substituted or unsubstituted aliphatic or aromatic groupn is an integer from 0 to 1Chemical compounds having structural formula I and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyperproliferative disorders.
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Arnold Lee
Calderwood David
Fernandez Isabel
Martinez Jose L. Ortego
Pascual Beatriz Gonzalez
Abbott & GmbH & Co. KG
O'Brien Gayle B.
Wilson James O.
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