Benzopyran derivatives and processes for the preparation thereof

Details Benzopyran derivatives and processes for the preparation thereof Benzopyran derivatives and processes for the preparation thereof

1992-05-21

1993-08-17

Lee, Mary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514424, 514456, 5142282, 5142335, 514252, 514256, 514212, 514414, 548525, 548464, 546269, 544 582, 544151, 544377, 544238, 544310, 540524, A61K 3144, A61K 3140, C07D40104, C07D40504

Patent

active

052369358

ABSTRACT:
The present invention relates to novel benzopyran derivatives of formula (I) which have superior selectivity in the treatment of hypertension by lowering blood pressure with a relaxation activity on vascular smooth muscle. The present invention also relates to processes for preparing such compounds; and to a pharmaceutical compositions containing such compounds as an active ingredient. ##STR1## wherein: R.sub.1 is --CN, --NO.sub.2, --OCX.sub.1 X.sub.2 X.sub.3, --NH.sub.2, --NHSO.sub.2 R.sup.A, ##STR2## --SO.sub.2 R.sup.C or --SO.sub.2 NR.sup.C R.sup.D wherein X.sub.1, X.sub.2 and X.sub.3 are, each independently, a fluorine, chlorine or hydrogen atom; R.sup.A and R.sup.B are, each independently, an amino, C.sub.1-6 alkoxy, C.sub.1-6 alkyl group or an optionally substituted phenyl group; and R.sup.C and R.sup.D are a hydrogen atom, or a C.sub.1-6 alkyl group or an optionally substituted phenyl group with a halogen atom, or a straight or branched C.sub.1-3 alkyl group;

REFERENCES:
patent: 4997846 (1991-05-01), Genain et al.

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