Benzodiazepine derivatives

Details Benzodiazepine derivatives Benzodiazepine derivatives

1976-08-02

1978-03-14

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424244, 424263, C07D24324

Patent

active

040790533

ABSTRACT:
Novel 1-substituted benzodiazepine derivatives and salt thereof having the formula, ##STR1## wherein R.sub.1 is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a lower alkoxy group or a trifluoromethyl group; R.sub.2 is a pyridyl group or a group of the formula ##STR2## wherein R.sub.5 and R.sub.6 represent individually a hydrogen atom, a halogen atom, a lower alkyl group or a trifluoromethyl group); R.sub.3 is a hydrogen atom or a lower alkyl group; R.sub.4 is a lower alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl group; m is 1 or 2; and n is an integer of 1 to 4, and a process for preparation thereof and pharmaceutical use of the same.
The benzodiazepine derivatives are effective as tranquillizers, muscle-relaxants and hypnotics.

REFERENCES:
patent: 3784542 (1974-01-01), Hellerbach et al.
patent: 4010154 (1977-03-01), Yamamoto et al.
Sternbach, et al., Some Aspects of Structure-Activity Relationship in Psychotropic Agents of the 1,4-Benzodiazepine Series CSIR New Delhi, India, (1966).

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