Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-06-06
2006-06-06
Low, Christopher S. F. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S230800, C514S211090, C514S232800, C514S279000
Reexamination Certificate
active
07056929
ABSTRACT:
A method for treating a living body afflicted with a cancer selected from lung and ovarian carcinoma, comprising the step of administering to the living animal body an amount of a compound selected from those of formula (I):wherein:X and Y represent group selected from hydrogen, halogen, mercapto, cyano, nitro, alkyl, trihaloalkyl, trihaloalkylcarbonylamino, —ORa, —NRaRb, —NRa—C(O)-T1, —O—C(O)-T1, —O-T2-NRaRb, —O-T2-ORa, —NRa-T2-NRaRb, —NRa-T2-ORa and —NRa-T2-CO2Ra wherein Ra, Rb, T1, T2are as defined in the description, or X and Y together form a methylenedioxy or ethylenedioxy,R1represents hydrogen or alkyl,R2represents a group selected from hydrogen, —ORa, —NRaRb, —NRa—C(O)-T1, —O—C(O)-T1, —O-T2-NRaRb, —O-T2-ORa, —NRa-T2-NRaRb, —NRa-T2-ORa and —NRa-T2-CO2Ra wherein Ra, Rb, T1and T2are as defined hereinbefore,R3and R4represent hydrogen or alkyl,W represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH— or —C(O)—CH(R8)— wherein R5, R6, R7and R8are as defined in the description,their isomers and N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same are useful in the treatment of cancer.
REFERENCES:
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Burbridge, M.F., Kraus-Berthier, L., Naze, M., Pierré, A., Atassi, G., and Guilbaud, N. Biological and Pharmacological Characterization of Three Models of Human Ovarian Carcinoma Established in Nude Mice: Use of the CA125 Tumour Marker to Predict Antitumour Activity. Int. J. Oncol., 15, 1155-1162, 1999.
El Omri Abdelhakim
Hickman John
Koch Michel
Michel Sylvie
Pfeiffer Bruno
Delacroix-Muirheid C.
Hueschen and Sage
Les Laboratoires Servier
Low Christopher S. F.
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