Benzimidazole vascular damaging agents

Details Benzimidazole vascular damaging agents Benzimidazole vascular damaging agents

2006-07-25

2006-07-25

Wang, Sheng Jun (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S389000, C514S391000, C514S394000, C514S622000, C514S709000, C514S708000

Reexamination Certificate

active

07081469

ABSTRACT:
Vascular damaging agents composed of substituted 5(6)-substituted benzimidazole-2-carbamates are provided. These agents are useful in the preparation of medicaments for the treatment of diseases involving neovascularisation, particularly for the treatment of solid tumors, macular degeneration, diabetic retinopathy, rheumatoid arthritis, psoriasis, and atherosclerosis. Embodiments include a 5(6)-substituted benzimidazole-2-carbamate of formula Iwherein A represents a multi-substituted alkyl group or aromatic ring.

REFERENCES:
patent: 3694455 (1972-09-01), Dunn
patent: 3928375 (1975-12-01), Diiwel et al.
patent: 3965113 (1976-06-01), Beard et al.
patent: 3984561 (1976-10-01), Loewe et al.
patent: 5763473 (1998-06-01), Elokdah et al.
patent: 2164690 (1973-07-01), None
patent: 2332343 (1975-01-01), None
Nare et al. Biochemical Pharmacology (1994), 48(12), 2215-22.
Kruse, L.I., et al., “Synthesis, Tubulin Binding, Antineoplastic evaluation, and Structure-Actvity Relationship of Oncodazole Analogues,” Journal of Medicinal Chemistry,, vol. 32, No. 2, Feb. 1989, pp. 409-417,XP002142971.
Lacey, E., et al., “Activity of Benzimidazole Carbamates Against L1210 mouse Leukaemia cells: Correlation with in Vitro Tubulin Polymerization assay,” Biochemical Pharmacology, vol. 34, No. 19, 1985, pp. 3603-3605, XP002056333.
Chemical Abstract of de Brabander, M.J., et al., “The effects of methyl5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl Carbamate. (R 17934: NSC 238159), a new synthetic antitumoral drug interfering with microtubles, on mammalian cells cultured in vitro,” p. 26; XP002143095, cited in the application abstract & Cancer Res., vol. 36, No. 3, 1976, pp. 905-916, Chemical Abstract, vol. 84, No. 21.
Khan, A.M. et al., “Studies on enteric anthelmintics: Impact of single point structural change on the activity profile,” Zeitschrift Fur Naturfoschung, B, vol. 43, No. 2, Feb. 1988, pp. 233-237.
Raeymaekers, A.H.M., et al., “Synthesis and Anthelmintic Activity of Alkyl-(5-acyl-1H-benzimidazol-2yl) carbamates,” Arzneimittel-Forschung, vol. 28 (I), No. 4, 1978, pp. 586-594, XP002142973.
Abuzar, S., et al., “Synthesis and anthelmintic activity of 2,2′-disubstitued 5,5-dibenzimidazolylsufides and sulfones,” Arzeimittel-forschung, vol. 36 (I), No. 3, Mar. 1986, pp. 416-419, XP002142974.
Database Crossfire “Online”, Beilstein Institut zur Foerderung der Chemischen Wissenschaften; XP 002142975, Beilstein Registry No. 4595458 & Indian J. Chem. Sect. B, vol. 19, No. 7, 1980, pp. 536-538.
Database Crossfire “Online” Beilstein Institut zur Foerderung der Chemischen Wissenschaften; XP 002142976, Beilstein Registry No. 5651135 & Indian J Chem. Sect. B, vol. 24, 1985, pp. 754-760.
Database Crossfire “Online” Beilstein Institut zur Foerderung der Chemischen Wissenschaften; XP002142977, Beilstein Registry No. 5622648 & Indian J. Chem. Sect. B, vol. 24, 1985, pp. 747-753.
Database Crossfire “Online” Beilstein Institut zur Foerderung der Chemischen Wissenschaften; XP 002142978, Beilstein Registry No. 5669479, 5670801, 5667941, 5667940, 5665325 & Indian J. Chem. Sect. B, vol. 24, 1985, pp. 730-732.
Database Crossfire “Online” Beilstein Institut zur Foerderung der Chemischen Wissenschaften; XP 002142978, Beilstein Registry No. 4615289, 4609187, & Indian J. Chem. Sect. B, vol. 23, No. 12, 1984, pp. 1274-1278.
Database Crossfire “Online” Beilstein Institut zur Foerderung der Chemischen Wissenschaften; XP 002142980, Beilstein Registry No. 6009722, 6007941, 6007769 & Indian J. Chem. Sect. B, vol. 24, 1985, pp. 178-181.

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