Benzimidazole derivatives

Details Benzimidazole derivatives Benzimidazole derivatives

1986-07-03

1988-09-06

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546199, 546271, 548325, 548329, 548333, A61K 31415, C07D23154

Patent

active

047693843

ABSTRACT:
Benzimidazole derivatives of the formula (I): ##STR1## or a pharmaceutically acceptable acid addition salt thereof wherein R.sup.1 is hydrogen or lower alkyl; R.sup.2 is ##STR2## or --C.tbd.C--Ar wherein Ar is phenyl unsubstituted or substituted by one to three substituents selected from the group consisting of halo, lower alkyl, hydroxy, unsubstituted or substituted lower alkoxy, aralkyloxy wherein the alkyl moiety is a lower alkyl moiety, lower alkenyloxy, lower alkynyloxy, difluoromethoxy, lower alkylamino, methylenedioxy, trifluoromethyl, cyano, lower alkylthio and lower alkylsulfinyl; R.sup.4, R.sup.5, R.sup.6 and R.sup.7 a hydrogen or lower alkyl or R.sup.4 and R.sup.5 together with the carbon atoms to which they are attached form a cyclopropyl ring; and R.sup.3 is hydrogen, lower alkyl, acyl or lower alkylsulphonyl are useful in the treatment of ulcers of the stomach and duodenum in humans and animals.

REFERENCES:
patent: 2170474 (1939-08-01), Graenacher et al.
patent: 3075991 (1963-01-01), Moyle et al.
patent: 3152142 (1964-10-01), Moyle et al.
patent: 3652580 (1972-03-01), Janiak et al.
patent: 3726684 (1973-04-01), Riester et al.

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