Benzimidazole compounds

Details Benzimidazole compounds Benzimidazole compounds

1994-12-09

1996-09-10

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514394, 514333, 514307, 514314, 546 70, 546256, 546167, 546144, 546304, 5462734, 5462694, 5462691, 548126, 5483061, 5483054, 548131, 5483021, 540495, 540494, 544139, C07D40114, A61K 3144

Patent

active

055546323

ABSTRACT:
The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.3, R.sup.4, R.sup.6 and R.sup.7 each have the meanings set forth in the specification.
The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.

REFERENCES:
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European Search Report for corresponding EPA 0616807A1-three (3) pages.
Chem. Abstracts, vol. 100, No. 17, abstract No. 139029t, Apr. 23, 1984, Hussein et al., "1-(para or meta-cinnamoylphenyl)-5-nitrobenzimidazoles", p. 644.
Potts et al., "Aromatic substitution by N-arylhydroxylamines-I", Tetrahedron, vo. 31, Sep. 1975, pp. 2163-2170.
J. Chem. Soc. (C), 1970, pp. 85-91; "Synthesis of Heterocyclic Compounds. Part II..sup.1 N--Arylazoles by Ullmann Condensation", by Khan and Polya.
Anathan et al., J. Med. Chem. 1993, 36, 479-490.
Fryer, R. I. Ligand Interactions at the Benzodiazepine Receptor. In "Comprehensive Medicinal Chemistry"; Hansch, C., Sammes, P. G. Taylor, J. B., Eds.; Pergamon Press: New York, 1990, vol. 3, pp. 539-541.
Maryanoff et al., J. Med. Chem. 1995, 38, 16-20.

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