Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-03-24
1996-09-10
Fan, Jane
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514394, 514364, 5142332, 514333, 514307, 514314, A61K 3144
Patent
active
055546307
ABSTRACT:
The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.3, R.sup.4, R.sup.6 and R.sup.7 each have the meanings set forth in the specification.
The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
REFERENCES:
patent: 5158969 (1992-10-01), Olesen et al.
patent: 5360809 (1994-11-01), Axelsson et al.
Principles of Psychopharmacology. Clark et al. Academic Press. 1970. pp. 166-167.
Shutske et al. J. Med. Chem. 1989, 32. 1805-1813.
Ananthan et al., J. Med. Chem. 1993, 36, 479-490.
Fryer, R. I. Ligand Interactions at the Benzodiazepine Receptor. In "Comprehensive Medicinal Chemistry"; Hansch, C., Sammes, P. G., Taylor, J. B., Eds.; Pergamon Press: New York, 1990, vol. 3, pp. 539-541.
Maryanoff et al., J. Med. Chem. 1995, 38, 16-20.
European Search Report for corresponding EPA 0616807A1--three (3) pages.
Chem. Abstracts, vol. 100, No. 17, abstract No. 139029t, Apr. 23, 1984, Hussein et al., "1-(para or meta-cinnamoylphenyl)-5-nitrobenzimidazoles", p. 644.
Potts et al., "Aromatic substitution by N-arylhydroxylamines-I", Tetrahedron, vo. 31, Sep. 1975, pp. 2163-2170.
J. Chem. Soc. (C), 1970, pp. 85-91; "Syntheses of Heterocyclic Compounds. Part II..sup.1 N-Arylazoles by Ullmann Condensation", by Khan and Polya.
Axelsson Oskar
Teuber Lene
W atjen Frank
Fan Jane
Meiji Seika Kaisha Ltd.
NeuroSearch A/S
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