Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-07-12
2005-07-12
Raymond, Richard L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S372000, C514S374000, C514S378000, C514S394000, C514S395000, C514S339000, C514S307000, C544S333000, C206S570000, C546S144000, C546S167000, C546S269700, C546S271400, C546S272400, C546S273400, C546S273700, C548S181000, C548S206000, C548S235000, C548S247000, C548S254000, C548S255000, C548S304700, C548S306100
Reexamination Certificate
active
06916819
ABSTRACT:
This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula IThe invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAAreceptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed.This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAAreceptors in tissue sections.
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El Azzaoui et al. {Tetrahedron Letters (1999), 40(25), 4677-4680 }.
Albaugh Pamela
Cai Guolin
Currie Kevin S.
Ghosh Manuka
Gustavson Linda M.
Habte Kahsay
McDonnell Boehnen & Hulbert & Berghoff LLP
Neurogen Corporation
Raymond Richard L.
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