Benzazolides and their employment in phosphate ester oligonucleo

Details Benzazolides and their employment in phosphate ester oligonucleo Benzazolides and their employment in phosphate ester oligonucleo

1982-04-08

1984-10-02

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, 548111, 548259, C07H 1910

Patent

active

044749473

ABSTRACT:
Benzazoles, including benzatriazoles and benzimidazoles are employed in phospate triester oligonucleotide synthesis. The benzazoles form arylbenzazolide coupling agents, and phosphorodibenzazolides. Processes employing these reagents are also disclosed.

REFERENCES:
patent: 3986967 (1976-10-01), Okorodu
patent: 4174285 (1979-11-01), Braid
patent: 4310662 (1982-01-01), Crea
Cole, B. H., "Making Genes with Machines", High Technology, vol. 1, No. 1, 60-68.
Itakura, et al., "A Modified Triester Method for the Synthesis of Deoxyribopolynucleotides", Car J. Chem., 41,3649 (1973).
Broka, C., et al., "Simplifications in the Synthesis of Oligonucleotide Blocks", Nucleic Acid Res. 8,5461, 1980.
Amarnath V. et al., "Chemical Synthesis of Oligonucleotides" Chem. Rev. 1977, 77, 183, (1977).
Itakura K. et al., "Chemical DNA Synthesis and Recombinant DNA Studies" Science 209, 1401 (1980).

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