Di-N.sup.6', O.sup.3 -Demethylistamycin A preparation

Details Di-N.sup.6', O.sup.3 -Demethylistamycin A preparation Di-N.sup.6', O.sup.3 -Demethylistamycin A preparation

1983-09-07

1984-10-02

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536124, 536 161, C07H 1522

Patent

active

044749465

ABSTRACT:
A new istamycin A derivative called di-N.sup.6', O.sup.3 -demethylistamycin A exhibits a high antibacterial activity against various bacteria, particularly Pseudomonas aeruginosa. This compound can be prepared by selective acylation of the methylamino group at the 4-position of 1,2',6'-tri-N-protected N.sup.4 -deglycyl-di-N.sup.6', O.sup.3 -demethylistamycin A with glycine or an N-protected derivative thereof, followed by N-deprotection.

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patent: 4382926 (1983-05-01), Umezawa et al.
patent: 4406891 (1983-09-01), Umezawa et al.

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