Benzazepine-, benzoxazepine- and benzothiazepine-n-acetic acid d

Details Benzazepine-, benzoxazepine- and benzothiazepine-n-acetic acid d Benzazepine-, benzoxazepine- and benzothiazepine-n-acetic acid d

1996-03-22

1997-10-14

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514213, 540491, 540523, A61K 3155, C07D26714, C07D28110, C07D48700

Patent

active

056772971

ABSTRACT:
Compounds with neutral endopeptidase (NEP) inhibitory activity corresponding to the formula I ##STR1## in which R.sup.1 is a lower alkoxy-lower-alkyl group whose lower alkoxy radical is substituted by a lower alkoxy group, or a phenyl-lower-alkyl or phenyloxy-lower-alkyl group which can optionally be substituted in the phenyl ring by lower alkyl, lower alkoxy or halogen, or a naphthyl-lower-alkyl group,

REFERENCES:
patent: 5438046 (1995-08-01), Norcini et al.
patent: 5457196 (1995-10-01), Warshawsky et al.
patent: 5504080 (1996-04-01), Karanewsky
patent: 5506259 (1996-04-01), Norcini et al.
De Lombaert et al., "Pharmacological Profile of a Non-Peptidic Dual Inhibitor . . . ", Biochemical and Biophysical Research Communications, vol. 204, No. 1 (Oct. 14, 1994), pp. 401-412.

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