Benzamidine derivatives and their use as anti-coagulants

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

544405, 5462751, C07D40110, C07D40310, A61K 31495

Patent

active

058831002

ABSTRACT:
This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.

REFERENCES:
patent: 4064169 (1977-12-01), Hamano et al.
patent: 5332822 (1994-07-01), Misra
patent: 5451700 (1995-09-01), Morrissey et al.
patent: 5583146 (1996-12-01), Kimball et al.
Tidwell, R. et al., "Strategies for Anticoagulation with Synthetic Protease Inhibitors, Xa Inhibitors Versus Thrombin Inhibitors," Thrombosis Research, (1980) 19:339-349.
Sturzebecher, J. et al., "Cyclic Amides of N.alpha.-arysulfonylaminoacylated 4-amidinophenylalanine--Tight Binding Inhibitors of Thrombin," Thrombosis Research, (1983) 29:635-642.
Kikumoto, R. et al., "Selective inhibition of Thrombin by dinecarboxylic Acid," Biochemistry, (1984) 23:85-90.
Sturzebecher, J. et al., "Synthetic Inhibitors of Serine Proteinases XXIII, Inhibition of Factor Xa by Diabidines", Thrombosis Research, (1980) 17:545-548.
Chauhan, P. et al., "Effect of new diamidines against Leishmania donovani infection," Indian Journal of Experimental Biology, (1993) 31:196-198.
Ashley, J. et al., "The Search for Chemotherapeutic Amidines. Part XVI. Amidinoanilino-1,3,5-triazines and Related Compounds", J. of the Chemical Society, (1960) 4525-4532.
Geratz, J. et al., "The Inhibition of Urokinase by Aromatic Diamidines" Thrombos. Diathes haemorrh. (Stuttg.), (1975)33:230-243.
Geratz, J. et al. "Novel Bis (benzamidino) Compounds with an Aromatic Central Link. Inhibitors of Thrombin, Pancreatic Kallikrein, Trypsin, and Complement" J. of Medicinal Chemistry, (1976) 19(5):634-639.
Chauhan, P. et al., "Antiparasitic Agents: Part VI-- Synthesis of 1,2-,1,3-&1,4-Bis(4-substituted aryloxy)benzenes & Their Biological Activities", Indian Journal of Chemistry, (1988) 27B:38-42.
Kaiser, B. et al., "Factor Xa Inhibitors as Novel Antithrombotic Agents: Facts and Perspectives" Cardiovascular Drug Reviews, (1994) 12(3):225-236.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Benzamidine derivatives and their use as anti-coagulants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzamidine derivatives and their use as anti-coagulants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzamidine derivatives and their use as anti-coagulants will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-817942

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.