Benzamide inhibitors of the P2X7 Ereceptor

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S231500, C544S182000, C544S112000

Reexamination Certificate

active

06974812

ABSTRACT:
The present invention provides benzamide inhibitors of the P2X7receptor of the formula:wherein R1-R3are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.

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Drug Development Research (1996), 37(3), p. 126.
“Benzamide Inhibitors of the P2X7 Receptor” U.S. Appl. No. 10/748,342, Filed Dec. 30, 2003.

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