Benzamide inhibitors of the P2X 7 receptor

Details Benzamide inhibitors of the P2X 7 receptor Benzamide inhibitors of the P2X 7 receptor

2007-02-13

2007-02-13

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S182000

Reexamination Certificate

active

11260075

ABSTRACT:
The present invention provides benzamide inhibitors of the P2X7receptor of the formula:wherein R1–R3are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.

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