Benzamide 2-hydroxy-3-diaminoalkanes

Details Benzamide 2-hydroxy-3-diaminoalkanes Benzamide 2-hydroxy-3-diaminoalkanes

2007-05-29

2007-05-29

Dentz, Bernard (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S354000, C514S355000, C514S437000, C514S617000, C544S406000, C546S163000, C546S298000, C546S316000, C546S323000, C548S248000, C548S267200, C548S323100, C548S374100, C549S023000, C549S072000, C549S404000, C564S185000

Reexamination Certificate

active

10829106

ABSTRACT:
The present invention relates to compounds of formula (I):useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are also useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

REFERENCES:
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5387742 (1995-02-01), Cordell
patent: 5441870 (1995-08-01), Seubert et al.
patent: 5593846 (1997-01-01), Schenk et al.
patent: 5604102 (1997-02-01), McConlogue et al.
patent: 5612486 (1997-03-01), McConlogue et al.
patent: 5720936 (1998-02-01), Wadsworth et al.
patent: 5721130 (1998-02-01), Seubert et al.
patent: 5744346 (1998-04-01), Chrysler et al.
patent: 5766846 (1998-06-01), Schlossmacher et al.
patent: 5811633 (1998-09-01), Wadsworth et al.
patent: 5850003 (1998-12-01), McLonlogue et al.
patent: 5877015 (1999-03-01), Hardy et al.
patent: 5877399 (1999-03-01), Hsiao et al.
patent: 5912410 (1999-06-01), Cordell
patent: 5942400 (1999-08-01), Anderson et al.
patent: 6045829 (2000-04-01), Liversidge et al.
patent: 6191166 (2001-02-01), Audia et al.
patent: 2002/0128255 (2002-09-01), Beck et al.
patent: WO 98/22597 (1998-05-01), None
patent: WO 99/64001 (1999-12-01), None
patent: WO 00/03819 (2000-01-01), None
patent: WO 00/17369 (2000-03-01), None
patent: WO 00/47618 (2000-08-01), None
patent: WO 01/10387 (2001-02-01), None
patent: WO 01/23533 (2001-04-01), None
patent: WO 2003/040096 (2005-05-01), None
Berge et al., (1977)J. Pharm. Sci.66(1):1.
Citron et al., (1992)Nature360:672-674.
Cornelius et al., (1994)Synthetic Communications24:2777-2788.
Dantzig et al., (1996)Cancer Research56:4171-4179.
Emilieu et al., (2000)Arch. Neurol.57:454.
Games et al., (1995)Nature373:523-527.
Gould et al., (1986)Int. J. Pharm.33:201-217.
Hardy et al., (1992)Nature Genet.1:233-234.
Hussain et al., (1999)Mol. Cell. Neurosci.14:419-427.
Hyafil et al, (1993)Cancer Research53:4595-4602.
Jones et al., (1991)J. Org. Chem.56:763-769.
Kang et al., (1987)Nature325:733-6.
Kitaguchi et al., (1981)Nature331:530-532.
Lin et al., (2000)PNAS USA97:1456-1460.
Luo et al., (2001)Nature Neuroscience4:231-232.
Pirttila et al., (1999)Neuro. Lett.249:21-4.
Rover et al., (2000)J. Med. Chem.43:1329-1338.
Sabbagh et al., (1997)Alz. Dis. Rev.3:1-19.
Saito et al., (1980)J. Med. Chem.23:1364-1372.
Selkoe et al., (1991)Neuron6:487.
Seubert et al., (1992)Nature359:325-327.
Sinha et al., (1999)Nature402:537-554.
Vassar et al., (1999),Science286:735-741.
Witherspoon et al., (1996)Clin. Cancer Res.2:7-12.
Yan et al., (1999)Nature402:533-537.
Zhou et al., (1999)Tetrahedron Ltr.40:2729-2732.

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