Chemistry: molecular biology and microbiology – Vector – per se
Patent
1995-06-06
1998-04-07
Wax, Robert A.
Chemistry: molecular biology and microbiology
Vector, per se
4352523, 43525233, 4352542, 435325, 536 2372, C12N 1563, C12N 1571, C12N 1585, C12N 1538, C12N 1579
Patent
active
057363900
ABSTRACT:
BCRF1 proteins are provided for treating conditions associated with excessive production of IFN-.gamma.. Also provided are expression vectors for producing BCRF1 proteins. Compositions of the invention are useful in treating a variety of disorders, including allergy, psoriasis, tissue rejection, and MHC-linked autoimmune diseases.
REFERENCES:
patent: 5256768 (1993-10-01), Millman
R. Baer, et al., "DNA sequence and expression of the B95-8 Epstein-Barr virus genome," Nature, 310:207-211, Jul. 19, 1984.
Andrew G.D. Bean, et al., "Interleukin 10 Protects Mice against Staphylococcal Enterotoxin B-Induced Lethal Shock," Infection and Immunity, 61 (10): 4937-4939, Nov. 1993.
Rene de Waal Malefyt, et al., "Interleukin 10(IL-10) Inhibits Cytokine Synthesis by Human Monocytes: An Autoregulatory Role of IL-10 Produced by Monocytes," J. Exp. Med., 174:1209-1220, Nov. 1991.
Joakim Dillner and Bengt Kallin, "The Epstein-Barr Virus Proteins," Advances in Cancer Research, 50:95-158, 1988.
David F. Fiorentino, et al., "Il-10 Inhibits Cytokine Production By Activated Macrophages," The Journal of Immunology, 147(11):3815-3822, Dec. 1, 1991.
Maureen Howard, et al, "Interleukin 10 Protects Mice from Lethal Endotoxemia," J. Exp. Med., 177:1205-1211, Apr. 1993.
Jay B. Horowitz, et al., "Autocrine growth inhibition of a cloned line of helper T cells," Proc. Natl. Acad. Sci. USA, 83:1886-1890, Mar. 1986.
Di-Hwei Hsu, et al. "Differential effects of IL-4 and IL-10 on IL-2-induced IFN-.gamma. synthesis and lymphokine-activated killer activity," J. of Immunol., 6:663-669, Jan. 27, 1992.
Di-Hwei Hsu, et al., "Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1," Science, 250:830-832, Nov. 9, 1990.
Graham S. Hudson, et al., "The Short Unique Region of the B95-8 Epstein-Barr Virus Genome," Virology, 147:81-98, 1985.
Arnaud Marchant, et al., "Interleukin-10 controls interferon-y and tumor necrosis factor production during experimental endotoxemia," Eur. J. Immunol., 24:1167-1171, 1994.
High O. McDevitt, "The Molecular Basis of Autoimmunity," Clinical Research, 34:163-175, 1995.
Kevin W. Moore, et al., "Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRF1," Science, 248:1230-1234, Jun. 8, 1990.
David A. Thorley-Lawson, "Immunological responses to Epstein-Barr virus infection and the pathogenesis of EBV-induced diseases," Biochimica et Biophysica Acta, 948-286, 1988.
Giovanna Tosato, "The Epstein-Barr Virus and the Immune System," Advances in Cancer Research, 49:75-125, 1987.
P. Vieira, et al., "Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: Homology to Epstein-Barr virus open reading frame BCRF1," Proc. Natl. Acad. Sci. USA, 88:1172-1176, Feb. 1991.
David F. Fiorentino, et al., "Two types of mouse T helper cell IV. Thy 2 clones secrete a factor that inhibits cytokine production by Th1 clones," Journal of Experimental Medicine, 170:2081-2095, Dec. 1989.
Ning Fei Go, et al., "Interleukin 10, a novel B cell stimulatory factor: Unresponsiveness of X chromosome-linked immunodeficiency B cells,"Journal of Experimental Medicine, 172(6):1625-1631, Dec. 1, 1990.
Gunnar von Heijne, "A new method for predicting signal sequence cleavage sites," Nucleic Acids Research, 14(11):4683-4690, 1986.
Kevin W, Moore, et al., "Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr Virus Gene BCRF1," Science, 248(4960):1230-1234, Jun. 8, 1990.
Kastelein Robert A.
Moore Kevin W.
Bugaisky Gabriel E.
Ching Edwin P.
Dow Karen B.
Macevicz Stephen C.
Schering Corporation
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