Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1997-12-22
2000-02-29
Marx, Irene
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
4352521, 549510, 549511, C12N 120, C12P 1702
Patent
active
060308184
ABSTRACT:
The present invention relates to a method of obtaining different biologically pure cultures of bacteria isolated from different species of Taxus such as Taxus canadensis. T. brevifolia, T. baccata, T. cuspidata, and T. hunnewelliana, wherein the bacteria produce in vitro taxanes and paclitaxel, and wherein the bacteria are of the genus Sphingomonas, Bacillus, Pantoea or Curtobacterium. Also, the present invention relates to a method of a bacterial mass production of at least one taxane or paclitaxel. There is also disclosed a novel bacterial taxane. The present invention also relates to the use of different biologically pure cultures of bacteria isolated from different species of Taxus, wherein the bacteria are able to biotransform pro-taxanes. There is also provided a process for improving taxanes and paclitaxel production of taxanes and paclitaxel producing bacteria which include culturing bacteria in the presence of a mutagenic agent for a period a time sufficient to allow mutagenesis. There is disclosed two new mutated bacteria which have an increased yield of pro-taxane biotransformation.
REFERENCES:
patent: 5322779 (1994-06-01), Strobel et al.
patent: 5561055 (1996-10-01), Page et al.
patent: 5861302 (1999-01-01), Stierle
Wani MC et al., 1971, J. Am. Chem. Soc., 93:2325-2327.
Nicolaou et al., 1994, Nature, 367:630-634.
Yukimune et al., 1996, Nature Biotechnology, 14:1129-1132.
Srinivasan et al., 1995, Biotechnology and Bioengineering, 47:666-676.
Strobel et al., 1996, Microbiology, 142:435-440.
Boissinot Maurice
Gagne Martin
Harvey Mario
Helie Marie-Claude
Landry Nathalie
BCM Developpement Inc.
Marx Irene
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