Bacterial hydroxylation of codeine

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

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435886, 435897, 435900, 514282, 546 44, C12P 1718

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active

047987928

ABSTRACT:
A microbial process for converting codeine to 14-hydroxycodeine is provided. This process comprises aerobically culturing codeine with bacteria of the genus Streptomyces for at least about 3 days in a rich medium such as soybean flour medium.

REFERENCES:
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Liras et al., Developments in Industrial Microbiology, 16, 401-405-1975.
Liras et al., Applied Microbiology, 30, 650-656, 1975.
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Rozza et al., Journal of Medicinal Chemistry, 18, 791-794, 1975.
Kunz, D. A., Abstracts of the Annual Meeting of the American Society of Microbiology, p. 247, Feb. 25, 1985.

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