Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1995-10-02
2000-09-19
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
4353201, 536 237, 536 2342, C12N 121, C12N 1574, C12N 1531
Patent
active
061210374
ABSTRACT:
The present invention relates to novel bacterial hemoglobin receptor proteins and genes that encode such proteins. The invention is directed toward the isolation, characterization, diagnostic and therapeutic use of bacterial hemoglobin receptor proteins, nucleic acid encoding such proteins, recombinant expression constructs comprising such nucleic acids and cells transformed therewith, and antibodies and epitopes of such hemoglobin receptor proteins. The invention relates particularly to hemoglobin receptor proteins and genes encoding such proteins from Neisseria species, especially N. meningitidis and serotypes thereof, and N. gonorrhoeae. Methods for the diagnostic and therapeutic use of the proteins, epitopes, antibodies and nucleic acids of the invention are also provided, including the use of the proteins, epitopes, antibodies and nucleic acids of the invention for the production of vaccines effective in providing immunization of a human against infection by pathogenic bacteria of Neisseria species.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: B14683202 (1990-11-01), Mullis et al.
Archibald and DeVoe, "Removal of Iron from Human Transferrin in Neisseria meningiditis," FEMS Microbiol. Lett. 6, 159-162 (1979).
Baggs and Neilands, "Molecular Mechanism of Requlation of Siderophore-mediated Iron Assimilation," Microbiol. Rev. 51, 509-518 (1987).
Braun and Hantke, in Winkelmann (ed.), Handbook of Microbial Iron Chelates, CRC Press: Boca Raton, Fla., pp. 107-138 (1991).
Calver et al., "Iron as a replacement for mucin in the establishment of meningococcal infection in mice," Can. J. Microbiol. 22, 832-838 (1976).
Cornelissen et al., "Gonococcal Transferrin-Binding Protein 1 is Required for Transferrin Utilization and Is Homologous to TonB-dependant Outer Membrane Receptors," J. Bacteriol. 174; 5788-5797 (1993).
Correia et al., "A Family of Small Repeated Elements with Some Transposon-like Properties in the Genome of Neisseria gonorrhoeae*," J. Biol. Chem. 263: 12194-12198 (1988).
Coulton and Pang, "Transport of Hemin by Hawmophilus influenzae Type b," Curr. Microbiol. 9, 93-98 (1983).
Dyer et al., "Effects of Serum Carrier Proteins on the Growth of Pathogenic Neisseriae with Heme-Bound Iron," Infect. Immun. 55, 2171-2175 (1987).
Fenno et al., Characterization of allele replacement in Streptococcus parasanguis: transformation and homologous recombination in a `nontransformable` streptococcus, Gene 130: 81-90 (1993).
Gerlach et al., "Characterization of Two Genes Encoding Distinct Transferrin-Binding Proteins in Different Actinobacillus pleuropneumoniae Isolates," Infect. Immun. 60, 3253-3261 (1992).
Gotschlich et al., "The DNA Sequence of the Structural Gene of Gonococcal Protein III and the Flanking Region Containing a Repetitive Sequence," J. Exp. Med. 165: 471-482 (1987).
Heller et al., "Suppression of the btuB451 mutation by mutations in the tonB gene suggests a direct interaction between TonB and TonB-dependent receptor proteins in the outer membrane of Escherichia coli," Gene 64: 147-153 (1988).
Henderson and Payne, "Characterization of the Vibrio cholerae Outer Membranes Heme Transport Protein HutA: Sequence of the Gene, Regulation of Expression, and Homology to the Family of TonB-Dependent Proteins," J. Bacteriol. 176: 3269-3277 (1994).
Hnatowich et al., "Radioactive Labeling of Antibody: A Simple and Efficient Method," Science 220: 613-615 (1983).
Holbien et al., "Enhancement of Neisseria meningiditis Infection in Mice by Addition of Iron Bound to Transferrin," Infect. Immun. 34, 120-125 (1981).
Jarosik et al., "A Functional tonB Gene is Required for Both Utilization of Heme and Virulence Expression by Haemophilus influenzae Type b," Infect. Immun. 62: 2470-2477 (1994).
Kellog et al., "Neisseria Gonorrhoeae I. Virulence Genetically Linked to Clonal Variation," J. Bacteriol. 85: 1274-1279 (1963).
Knight et al., "Identification and characterization of a novel insertion sequence, IS1106, downstream of the porA gene in B15 Neisseria meningitidis," Mol. Microbiol. 6: 1565-1573 (1992).
Koebnik, "Structural organization of TonB-dependent receptors," Trends Microbiol. 1: 201 (1993).
Lee and Hill, "Identification of an outer-membrane haemoglobin-binding protein in Neisseria meningitidis," J. Gen. Microbiol. 138, 2647-2656 (1992).
Lee, "Isolation and characterization of haemin-binding proteins from Neisseria meninigitidis," Microbiol. 140: 1473-1480 (1994).
Lundrigan & Kadner, "Nucleotide Sequence of the Gene for the Ferrienterochelin Receptor FepA in Excherichia coli," J. Biol. Chem. 261: 10797-10801 (1986).
Martek and Lee, "Acquisition of Heme Iron by Neisseria menigitidis Does Not Involve Meningococcal Transferrin-Binding Proteins," Infect. Immun. 62: 700-703 (1994).
Meares et al., "Conjugation of Antibodies with Bifunctional Chelating Agents: Isothiocyanate and Bromoacetamide Reagents, Methods of Analysis, and Subsequent Addition of Metal Ions," Anal. Biochem. 142: 68-78 (1984).
Mickelson et al., "Ability of Neisseria gonorrhoeae, Neisseria meningiditis, and Commensal Neisseria Species to Obtain Iron from Lactoferrin," Infect. Immun. 35, 915-920 (1982).
Nassif et al., "Tumour necrosis factor alpha antibody protects against lethal meningococcaemia," Mol. Microbiol. 6: 591-597 (1992).
Nassif et al., "Antigenic variation in pilin regulates adhesion of Neisseria meningitidis to human epithelial cells," Mol. Microbiol. 8: 719-725 (1993).
Otto et al., "Transferrins and Heme-Compounds as Iron Sources for Pathogenic Bacteria," Crit. Rev. Microbiol. 18, 217-233 (1992).
Pettersson et al., "Identification of the iroA Gene Product of Neisseria meningitidis as a Lactoferrin Receptor," J. Bacteriol. 176: 1764-1766 (1994).
Pettersson et al., "Molecular Characterization of the 98-Kilodalton Iron-Regulated Outer Membrane Protein of Neisseria menigitidis," Infect. Immun. 61: 4724-4733 (1993).
Postle, "TonB and the Gram-Negative dilemma," Mol. Microbiol. 133: 891-898 (1990).
Riboli et al., "Expression of Bordetella pertussis fimbrial (fim) genes in Bordetella bronchiseptica: fimX is expressed at a low level and vir-regulated," Microb. Pathogen 10: 393-403 (1991).
Saiki et al., "Enzymatic Amplification of .beta.-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia," Science 230: 1350-1354 (1988).
Schoffler and Braun, "Transport across the outer membrane of Escherichia coli K12 via the FhuA receptor is regulated by the TonB protein of the cytoplasmic membrane," Molec. Gen. Genet. 217: 378-383 (1989).
Schryvers and Morris, "Identification and Characterization of the Human Lactoferrin-Binding Protein from Neisseria menigitidis," Infect. Immun. 56, 1144-1149 (1988).
Schryvers and Morris, "Identification and Characterization of the transferrin recepotr for Neisseria menigitidis," Mol. Microbiol. 2, 281-288 (1988).
Schryvers et al., "Comparison of the Abilities of Different Protein Sources of Iron to Enhance Neisseria-Meninigitidis Infection in Mice," Infect. Immun. 57(8): 2425-2429 (1989).
Schryvers, "Characterization of the human transferrin and lactoferrin receptors in Haemophilus influenzae," Mol. Microbiol. 2, 467-472 (1988).
Stojiljkovic and Hantka, "Hemin uptake system of Yersinia enterocolitica: similarities with other TonB-dependent systems in Gram-negative bacteria," EMBO J. 11, 4359-4367 (1992).
Stoebner and Payne, "Iron-Requlated Hemolysin Production and Utilization of Heme and Hemoglobin by Vibrio cholerae, " Infect. Immun. 56, 2891-2895 (1988).
Struyve et al., "Carboxy-terminal Phenylalanine is Essential for the Correct Assembly of a Bacterial Outer Membrane Protein," J. Mol. Biol. 218: 141-148 (1991).
Walters, "Computer-Assisted Modeling of Drugs," in Klegerman & Groves, eds., 1993, Pharmaceutical Biotechnology, Interpharm Press: Buffalo Grove, IL., pp. 165-174.
Weinberg, "Iron Witholding: A Defense against Infection and Neoplasia," Physiological. Rev. 64, 65-102 (1984).
West and Sparling, "Response of Neisseria gonorrhoeae to Iron Limitation: Alterations in Expression of Membrane Protein
Heffron Fred
Hwa Vivian
Nassif Xavier
So Magdalene
Stojiljkovic Igor
Hayes Robert C.
Hutzell Paula K.
LandOfFree
Bacterial hemoglobin receptor genes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bacterial hemoglobin receptor genes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bacterial hemoglobin receptor genes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1071604