Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1988-10-19
1991-09-24
Ceperley, Mary E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 792, 435 793, 435 21, 435 28, 435 7021, 435125, 4351722, 43524027, 436543, 436544, 436546, 436548, 530387, 530408, 530807, 935103, 935110, G01N 33533, G01N 33535
Patent
active
050513613
ABSTRACT:
This invention relates to a method for the immunoassay of AZT (3'-azido-3'-deoxythymidine), also known as zidovudine, in biological fluids such as serum, semen, plasma and urine, as well as other body fluids. The invention also includes (1) various novel analogs of AZT useful in preparing immunogens for antibodies to AZT and in preparing labeled AZT, (2) immunogens for antibodies to AZT, (3) monoclonal and polylonal antibodies to AZT, (4) labeled AZT analogs and (5) diagnostic test kits for the immunoassay.
REFERENCES:
patent: 4724232 (1988-02-01), Rideout et al.
patent: 4824941 (1989-04-01), Gordon et al.
Blum, M. Robert, Ph.D. et al., "Pharmacokinetics and Bioavailability of Zidovudine in Humans", The American Journal of Medicine, vol. 85 (suppl 2A), Aug. 29, 1988, pp. 189-194.
Furman, Phillip A. et al., "Phosphorylation of 3'-Azido-3'-Deoxythymidine and Selective Interaction of the 5'-Triphosphate with Human Immunodeficiency Virus* Reverse Transcriptase", Proceedings of the National Academy of Sciences, U.S.A., vol. 83, Nov. 1986, pp. 8333-8337.
Glinski, Ronald P. et al., "The Synthesis of Phosphorylated 3'-Amino-3'-Deoxythymidine and 5'-Amino-5'-Deoxythymidine", Chemical Communications, 1970, pp. 915-916.
Glinski, Ronald P. et al., "Nucleotide Synthesis. IV..sup.1 Phosphorylated 3'-Amino-3'-Deoxythymidine and 5'-Amino-5'-Deoxythymidine and Derivatives.sup.2,3 ", J. Org. Chem., vol. 38, No. 25, 1973, pp. 4299-4305.
Good, S. S. et al., "Biotransformation in Various Species and in Humans of 3'-Azido-3'-Deoxythymidine, A Potential Agent for the Treatment of Aids", Abstract No. 1690, Federation Proceedings, Federation of American Societies for Experimental Biology, vol. 45, No. 3, Mar. 1, 1986, p. 444.
Good, Steven S. et al., "Simultaneous Quantification of Zidovudine and Its Glucuronide in Serum by High-Performance Liquid Chromatography", Journal of Chromatography, 431 (1988), pp. 123-133.
Henry, Keith, M. D. et al., "Concurrent Zidovudine Levels in Semen and Serum Determined by Radioimmunoassay in Patients with Aids or Aids-Related Complex", JAMA, vol. 259, No. 20, May 27, 1988, pp. 3023-3026.
Horwitz, Jerome P. et al., "Nucleosides, V. The Monomesylates of 1-(2'-Deoxy-.beta.-D-Lyxofuranosyl)Thymine.sup.1,2," Journal of Organic Chemistry, vol. 29, Jul., 1964, pp. 2076-2078.
Imazawa, M. and F. Eckstein, "Synthesis of 3'-Azido-2',3'-Dideoxyribofuranosylpurines", Journal of Organic Chemistry, vol. 43, No. 15, 1978, pp. 3044-3048.
Incstar Corporation, "ZDV-TRAC.TM. RIA: AZT, Retrovir, Zidovudine", Incstar Science Technology and Research, Package Insert, Part #11688, Revised Jun. 1988.
Krasny, H. C. and S. S. Good, "Pharmacokinetics and Metabolism of Azidothymidine in the Dog", Abstract No. 311, Federation Proceedings, Federation of American Societies for Experimental Biology, vol. 45, No. 3, Mar. 1, 1986, p. 207.
Krodstad, D. J. et al., "Fluorescence Polarization Immunoassay for AZT", Abstract No. 1464, Program and Abstracts of the Twenty-Eight Interscience Conference on Antimicrobial Agents and Chemotherapy, ASM News, vol. 54, No. 8, 1988, p. 371.
Krodstad, D. J. et al., "Fluorescence Polarization Immunoassay for Azidothymidine", ASM News (American Society for Microbiology), vol. 54, No. 8, Aug., 1988, No. 1464.
Matsuda, Akira et al., "Nucleosides. 115. Reaction of 3'-O-Mesythymidine. Formation of 1-(3-Azido-2,3--Dideoxy-.beta.-D-Threo-Pentofuranosyl)Thymine and Its Conversion into 6,3'-Imino-1-(2,3-Dideoxy-.beta.-D-Threo-Pentofuranosyl)Thymine.sup.1," Journal of Organic Chemistry, vol. 45, No. 16, 1980, pp. 3274-3278.
Quinn, Richard P. et al., "A Radioimmunoassay for Azidothymidine (AZT) Using a High Specific Activity Tritiated Antigen", Abstract No. 1465, Program and Abstracts of the Twenty-Eighth Interscience Conferene on Antimicrobial Agents and Chemotherapy, ASM News, vol. 54, No. 8, 1988, p. 371.
Quinn, R. P. et al., "Radioimmunoassay for Azidothymidine Using a High-Specific-Activity Tritiated Antigen", Program No. 1465, 1988 ICAAC Program, ASM News, vol. 54, No. 8, 1988.
Murray Dennis M.
Stenglein Kenneth J.
Ceperley Mary E.
Sigma Chemical Company
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