Azolidinediones useful for the treatment of diabetes, dyslipidem

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

544 37, 544 38, 544 42, 544 43, 544 44, 544 45, 544 46, 544102, 544103, 544104, 5142252, 5142255, 5142258, 5142262, A61K 31535, A61K 3154, C07D26536, C07D27916

Patent

active

061599662

ABSTRACT:
A compound of formula (I) ##STR1## its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates, wherein R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are the same or different; R.sup.1 and R.sup.2 together represent along with carbon atoms to which they are attached an aromatic cyclic structure containing 5-6 ring atoms which may optionally be substituted; X represents a heteroatom selected from oxygen or sulfur; R.sup.7 represents hydrogen atom, hydroxy, alkoxy, halogen, lower alkyl group or optionally substituted aralkyl group or forms a bond together with R.sup.8 ; R.sup.8 represents hydrogen atom, hydroxy, alkoxy, halogen, lower alkyl group or optionally substituted aralkyl or R.sup.8 forms a bond together with R.sup.7 ; B represents an oxygen atom or a sulfur atom; Y represents an oxygen atom or a sulfur atom, n is an integer ranging from 1 to 4 and m is an integer of zero or one, compositions containing compounds of formula (I) and methods of use of the compounds are described.

REFERENCES:
patent: 3225037 (1965-12-01), Zenitz et al.
patent: 3869394 (1975-03-01), Daniels et al.
patent: 3912727 (1975-10-01), Daniels
patent: 4873255 (1989-10-01), Yoshioka
patent: 5002953 (1991-03-01), Hindley
patent: 5037842 (1991-08-01), Goldstein
patent: 5468762 (1995-11-01), Malamas
patent: 5478851 (1995-12-01), Cantello
patent: 5478852 (1995-12-01), Olefsky
patent: 5478853 (1995-12-01), Regnier
patent: 5521201 (1996-05-01), Hindley
patent: 5955481 (1999-09-01), Ohara et al.
Messier, C. et al., Behavioral Brain Research , 75 (1966) 1-11.
Sohda, T. et al., Chem Pharm Bull. 30, 10 (1982), 3580-3600.
Clark, et al. J. Med. Chem 34 (1991) 319-325.
Dow, R. L. et al., J. Med. Chem 34 (1991) 1538-1544.
Hulin, et al., J. Med. Chem 35 (1992) 1853-1864.
Sohda, T. et al., J. Med. Chem 35 (1992) 2617-2626.
Goldstein, et al., J. Med. Chem. 36 (1993) 2238-2240.
Cantello, et al., J. Med. Chem 37 (1994) 3977-3985.
English Translation of JP-A-0912575.
M. Modan, et al., J. Clin. Invest. (1985) vol. 75, pp. 809-817.
O. G. Kolterman, et al., J. Clin. Invest. (1981) vol. 68, pp. 957-969.
E. Ferrannini, et al., The New England Journal of Medicine (1987) vol. 317, pp. 350-357.
D.C. Shen, et al., J. Clin. Endocrinol. Metab. (1988) vol. 66, pp. 580-583.
Goodman & Gilman's The Pharmacological Basis of Therapeutics, Ninth Edition, pp. 1496-1497.
Clifford Bailey, "Potential New Treatments for Type 2 Diabetes", Chemistry & Industry, Jan. 19, 1998, pp. 53-57.
T. Antonucci, et al. "Imparied Glucose Tolerance is Normalized by Treatment with the Thiazolidinedione Troglitazone" Diabetes Care, vol. 20, No. 2, Feb. 1997, pp. 188-193.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Azolidinediones useful for the treatment of diabetes, dyslipidem does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Azolidinediones useful for the treatment of diabetes, dyslipidem, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Azolidinediones useful for the treatment of diabetes, dyslipidem will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-217310

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.