Azabicyloalkane phenyl substituted alkane carboxylates, their pr

Details Azabicyloalkane phenyl substituted alkane carboxylates, their pr Azabicyloalkane phenyl substituted alkane carboxylates, their pr

1986-04-17

1987-12-15

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548452, C07D20902, H61K 3140

Patent

active

047133910

ABSTRACT:
This invention relates to novel compositions, their preparation and the use thereof as anticholinergic agents in the treatment or prophylaxis of organophosphate or nerve gas poisoning in animals. These compositions and pharmaceutical preparations containing them in their free base form and acid addition salts thereof are represented by the formula ##STR1## wherein R represents lower alkyl groups containing 1 to 7 carbon atoms; R.sup.1 represents hydrogen, phenyl, cyclohexyl, and cyclopentyl; and R.sup.2 represents lower alkyl groups containing 1 to 7 carbon atoms, hydroxymethyl, and hydroxyl.

REFERENCES:
patent: 4499099 (1985-02-01), Watts
patent: 4533498 (1985-08-01), Blaney et al.
Furstoss et al., Chem. Abstracts, 72, (1970), entry 111268z.
House, Modern Synthetic Reactions, W. A. Benjamin, Inc., N.Y., (1965), pp. 4-55.
Kaplan, J. Am. Chem. Soc., 88, (1966), 4970-4971.
Sonntag, Chem. Revs., 52, (1953), 312-399.

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