Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-07-16
1993-02-16
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142242, 5142305, 544349, 544 47, 544105, A61K 3154, A61K 31535, A61K 31495, A61K 3150
Patent
active
051871661
ABSTRACT:
Azabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A is a group of formula (a), (b) or (c): ##STR2## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.10 alkyl, aralkyl or di(C.sub.1 -C.sub.4) alkylamino(C.sub.1 -C.sub.6)alkyl;
REFERENCES:
patent: 2970144 (1961-01-01), Zirkle
patent: 4352802 (1982-10-01), Blaney
patent: 4789673 (1988-12-01), Donatsch et al.
patent: 4800225 (1989-01-01), Smith
patent: 4803199 (1989-02-01), Donatsch et al.
patent: 4910207 (1990-03-01), Donatsch et al.
Nikitskaya et al., "Synthesis of 7-hydroxy-9-methyl-3,9-diazabicyclo [3.3.1]nonane and some derivatives", Chemical Abstracts, vol. 62 (1965) 14678d.
The New England Journal of Medicine, vol. 305, No. 16, Oct. 15, 1981, pp. 905-909, R. J. Gralla et al., "Antiemetic Efficacy of High-Dose Metoclopramide: Randomized Trials with Placebo and Prochlorperazine in Patients with . . . .".
The Lancet, Jun. 27, 1987, vol. 1, No. 8548, pp. 1461-1463, D. Cunningham, et al., "Prevention of Emesis in Patients Receiving Cytotoxic Drugs by GR380321, a Selective 5-HT.sub.3 Receptor Antagonist".
Chem. Pharm. Bull., vol. 19, No. 8, 1971, pp. 1696-1699, M. Murakami, et al., "An Improved Synthesis of Metoclopramide".
J. Org. Chem., vol. 23, Apr. 1958, p. 621, R. F. Smith, et al., "Diindazolo[2,3-.alpha., 2',3'-d]Pyrazine-7,14-Dione".
J. Org. Chem., 26, Feb. 1961, pp. 395-407, C. L. Zirkle, et al., "The Isomeric 3-Oxa- and 3-Thiagranatanin-7-Ols and Their Derivatives; Reduction of Bicyclic Amino Ketones Related to Tropinone.sup.1,2 ".
Physiological Reviews, vol. 53, No. 1, Jan. 1973, A. S. Paintal, "Vagal Sensory Receptors and Their Reflex Effects", pp. 159-210.
Nature, vol. 316, Jul. 11, 1985, pp. 126-131, B. P. Richardson, et al., "Identification of Serotonin M-Receptor Subtypes and Their Specific Blockade by a New Class of Drugs".
Hagihara Koichiro
Hayakawa Toru
Kikuchi Haruhiko
Mino Setsuko
Satoh Hiroaki
Grumbling Matthew V.
Nisshin Flour Milling Co. Ltd.
Shah Mukund J.
LandOfFree
Azabicyclo derivatives and their use as antiemetics does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Azabicyclo derivatives and their use as antiemetics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Azabicyclo derivatives and their use as antiemetics will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2148169