(Aza)indole derivative and use thereof for medical purposes

Details (Aza)indole derivative and use thereof for medical purposes (Aza)indole derivative and use thereof for medical purposes

2011-08-23

2011-08-23

Young, Shawquia E (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S300000, C514S415000, C544S236000, C544S280000, C546S113000, C548S503000, C548S509000

Reexamination Certificate

active

08003647

ABSTRACT:
The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to (aza)indole derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro or cyano and the like; ring J represents aryl or heteroaryl and the like; Q represents carboxy or 5-tetrazolyl and the like; Y represents H, OH, NH2, halogen, nitro, alkyl, alkoxy and the like; X1, X2and X3independently represent CR2or N; R1and R2independently represent halogen, cyano, haloalkyl, A-D-E-G, —N(-D-E-G)2and the like, in the formula, A represents a single bond, O, S and the like; D and G independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E represents a single bond, O, S, COO, SO2and the like.

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