Autoantigenic fragments, methods and assays

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide

Reexamination Certificate

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Reexamination Certificate

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06855515

ABSTRACT:
The present invention provides a method of producing autoantigens, compositions comprising autoantigenic fragments and methods of using autoantigenic fragments in the treatment of a condition associated with an autoimmune response. Also provided are assays for the detection or assessment of an autoimmune response.

REFERENCES:
Casciano, et al., “Selective Cleavage of Nuclear Autoantigens During CD95 (Fas/APO-1)-mediated T Cell Apopsotis”, J. Exp. Med., vol. 184, Aug. 1996, pp. 765-770.
Casciano, et al., “Antinuclear autoantibodies: probes for defining proteolytic events associated with apoptosis”, Molecular Biology Reports, vol. 23, pp. 211-216, 1996.
Rosen, et al, “Macromolecular Substrates for the ICE-Like Proteases During Apoptosis”, Journal of Cellular Biochemistry, vol. 64, pp. 50-54, 1997.
Bach, et al., “New clues to systemic lupus”, Lancet, vol. 350, pp. 11, 1997.
Beidler, et al., “The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis”, J. Biol. Chem., vol. 270, pp. 16526-16528, 1995.
Bockenstedt, et al., “Self-peptides in the initiation of lupus autoimmunity”, J. Immunol., vol. 154, pp. 3516-3524, 1995.
Bump, et al., “Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35”, Science, vol. 269, pp. 1885-1888, 1995.
Burlingame, et al., “Genesis and evolution of antichromatin autoantibodies in muring lupus implicates T-dependent immunization with self-antigen”, J. Clin. Invest., vol. 91, pp. 1687-1696, 1993.
Casciola-Rosen, et al, “Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic kertinocytes”, J. Exp. Med., vol. 179, pp. 1317-1330, 1994.
Casciola-Rosen, et al., “Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death”, J. Biol. Chem., vol. 269, pp. 30757-30760, 1994.
Casciola-Rosen, et al., “DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis”, J. Exp. Med., vol. 182, pp. 1625-1634, 1995.
Casciola-Rosen, et al., “Apopain/CPP32 cleaves proteins that are essential for cellular repair: A fundamental principal of apoptotic death”, J. Exp.Med., vol. 183, pp. 1957-1964, 1996.
Casciola-Rosen, et al., “Ultraviolet light-induced keratinocyte apoptosis: A potential mechanism for the induction of skin lesions and autoantibody production in L.E.”, Lupus, vol. 6, pp. 175-180, 1997.
Chinnaiyan, et al., “The Cell-Death Machine”, Curr. Biol., vol. 6, pp. 555-562, 1996.
Chinnaiyan, et al., “Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3”, Curr. Biol., vol. 6, pp. 897-899, 1996.
Darmon, et al., “Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation”, J. Biol. Chem., vol. 271, pp. 21709-21712, 1996.
Darmon, et al., “Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B”, Nature, vol. 377, pp. 446-448, 1995.
Deveraux, et al., “X-linked IAP is a direct inhibitor of cell-death proteases”, Nature, vol. 38, pp. 300-304, 1997.
Diamond, et al., “The role of somatic mutation int he pathogenic anti-DNA response”, Ann. Rev. Immunol., vol. 10, 731-757, 1992.
Duan, et al., “ICE-LAP6, a novel member pf tje ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B”, J. Biol. Chem., vol. 271, pp. 16720-16724.
Fernandes-Alnemri, et al., In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains, Proc. Natl. Acad. USA, vol. 93, pp. 7464-7469, 1996.
Froelich, et al., “Granzyme B perforin-mediated apoptosis of jurkat cells results in cleavage of poly(ADP-ribose)polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment”, Biochem. Biophys. Res. Commun., vol. 227, pp. 658-665. 1996.
Froelich, et al., “New paradigm for lymphocyte granule-mediated cytotoxicity—Target cells bind and internalize granzyme B, but an endosomolytic agent is necessage for cytoxolic delivery and subsequent apoptosis”, J. Biol. Chem., vol. 271, pp. 29073-29079, 1996.
Ghayur, et al., “Proteolytic activation of protein kinase C d by an ICE/CED-3-like protease induces features of apoptosis”, J. Exp. Med., vol. 184, pp. 2399-2404, 1996.
Greidinger, et al., “Sequential activation of three distinct ICE-like activities in Fas-ligated Jurkat cells., ”FEBS Lett., vol. 390, pp. 299-303, 1996.
Gu, et al., Processing and Activation of CMH-1 by Granzyme B., J. Biol. Chem., vol. 271, pp. 10816-10820, 1996.
Heusel, et al., “Cytocoxic lymphocytes require gramzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells”, Cell, vol. 76, pp. 997-987, 1994.
Irmler, et al., Inhibition of death receptor signals by cellular FLIP, Nature, vol. 388, pp. 190-195, 1997.
Jacobson et al., “Programmed cell death in animal development”, Cell, vol. 88, pp. 347-354, 1997.
Jans, et al., “Nuclear transport of granzyme B (fragmentin 2). Dependence on perforin in vivo and cytosolic factors in vitro”, J. Biol. Chem., vol. 271, pp. 30781-30789, 1996.
Krajewska, et al., “Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease”, Cancer Res., vol. 57, pp. 1605-1613, 1997.
Krajewski, et al., “Immunolocalizationo f the ICE/Ced-3-family protease, CPP32 (Caspase-3), in non-Hodgkin's lymphomas, chronic lymphocytic leukemias, and reactive lymph nodes”, Blood, vol. 89, pp. 3817-3825, 1997.
Lanzavecchia, et al., “How can cryptic epitopes trigger autoimmunity?”, J. Exp. Med., vol. 181, pp. 1945-1948, 1995.
Liu, et al., “DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis”, Cell, vol. 89, pp. 175-184, 1997.
Mamula, et al., “The inability to process a self-peptide allows autoreactive T cells to escape tolerance”, J. Exp. Med., vol. 177, pp. 567-571, 1993.
Martin, et al., “The cytotoxic cell protease gramzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism”, EMBO J., vol. 15, pp. 2407-2416, 1996.
Martin, et al., “Protease activation during apoptosis: Death by a thousand cuts?”, Cell, vol. 82, pp. 349-352, 1995.
McGahon, et al., Regulation of the Fas apoptotic cell death pathway by Abl. J. Biol. Chem., vol. 270, pp. 22625-22631, 1995.
Muzio, et al., “FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex”, Cell, vol. 85, pp. 817-827, 1996.
Nicholson, et al., Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis, Nature, vol. 376, pp. 37-43, 1995.
Nicholson, et al., “Caspases: Killer proteases”, TIBS, vol. 22, pp. 299-306, 1997.
Odake, et al., “Human and murine cytotoxic T lymphocyte serine proteases: Subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins”, Biochemistry, vol. 30, pp. 2217-2227, 1991.
Pinkoski, et al., “Binding of granzyme B in the nucleus of target cells. Recognition of an 80 kDa protein”, J. Biol. Chem., vol. 271, pp. 10225-10229, 1996.
Podack, et al., “Cytolytic T cell granules. Isolation, structural, biochemical and functional characterization”, J. Med. Exp., vol. 160, pp. 695-710, 1984.
Poe, et al., “Human cytotoxic lymphocute gramzyme B: Its purification from granules and the characterization of substrace

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