Attenuated strains of leishmania and uses thereof

Details Attenuated strains of leishmania and uses thereof Attenuated strains of leishmania and uses thereof

1996-05-06

2000-12-19

Navarro, Albert

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Protozoa, media therefor

424 931, 424 932, 424 9321, 4241841, 4242651, 4242691, 4352581, 4353201, 536 232, C12N 110, A61K 3900, A61K 3938, A61K 39002

Patent

active

061626384

ABSTRACT:
Attenuated strains of Leishmania are provided in which at least one gene contributing to virulence of the strain and expressed in both the promastigote and amastigote forms of the strain is functionally disabled, such as, by deleting at least a portion of the gene or by mutagenesis of the gene. The attenuated strain may be used for administration to a host to confer protection against disease caused by a virulent Leishmania strain or as a diagnostic reagent.

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