Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-04-03
1998-09-01
Marschel, Ardin H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514419, 536 253, 536 2532, 546270, 546271, 5483111, 5483124, A01N 4304, A01N 4338, C07H 2100, C07D23302
Patent
active
058011552
ABSTRACT:
Minor groove binding molecules are covalently bound to oligonucleotides which in their base sequence are complementary to a target sequence of single stranded or double stranded DNA, RNA or hybrids thereof. The covalently bound oligonucleotide minor groove binder conjugates strongly bind to the target sequence of the complementary strand.
REFERENCES:
patent: 4835263 (1989-05-01), Nguyen et al.
patent: 5237101 (1993-08-01), Nicolaou et al.
patent: 5395849 (1995-03-01), Wittman et al.
patent: 5446137 (1995-08-01), Maag et al.
Boder et al. Studies on the total synthesis of CC-1065: Preparation of a dimer/trimer/tetramer (CDPI dimer/trimer/tetramer) and development of methodology for PDE-I dimer methyl este, 1987.
Rao et al. "Synthesis of novel thiazole-containing DNA minor groove binding oligopeptides related to the antibiotic distamycin" J. Org. Chem., vol. 55, pp. 728-737, 1990.
Tabone et al. "Factors influencing the extent and regiospecificity of cross-linkk formation between single-stranded DNA and reactive complementary oligodeoxynucleotides" Biochemistry, vol. 33, pp. 375-383, 1994.
Webb, Thomas R. and Matteucci, Mark D. 1986 "Hybridization triggered cross-linking of deoxyoligonucleotides", Nucleic Acids Res., 14, 7661-7674.
Webb, T.R.; Matteucci, M.D. J. Am Chem. Soc., 1986, 108, 2764.
Kazimierczuk et al. J. Am. Chem. Soc., 1984, 106, 6379-6382.
Robins et al. Can. J. Chem., 60:554 (1982).
Robins et al. J. Org. Chem. 1983, 48:1854.
Sonveaux, Bioorganic Chemistry, 14:274-325 (1986).
Jones in "Oligonucleotide Synthesis, a Practical Approach", M.J. Gait, Ed., IRL Press, pp. 23-34 (1984).
Gibson, K.J., & Benkovic, S.J. (1987) Nucleic Acids Res., 15, 6455.
Boger, R.S. Coleman, and B.J. Invergo, J. Org. Chem., (1987), vol. 52, 1521-1530.
Grehn, L.V. Ragnarsson, J. Org. Chem., 1981, 46, 3492-3497.
Orum et al. Nucleic Acid Research, (1993) 21: 5332-5336.
Gamper, H.B. et al. Mucleic Acids Res., 1993 vol. 21 No. 1, 145-150.
M. Gait (ed.), Oligonucleotide Synthesis, A Practical Approach. IRL Press, 1984, Oxford, UK, pp. 35-81.
Petrie, C.R. et al. Bioconjugate Chemistry, 1992, 3, 85-87.
Jost, J.-P., et al. (1989) "Quantitative presipitation of short oligonucleotides with low concentrations of cetyltrimethylammonium bromide" Nucleic Acids Res. 17, 2143.
Godovikov, T.S. et al. 1989. Bioorgan. Khim, 15, 1246-1259.
Lokhov, S.G. et al. 1992. Bioconjugate Chem. 3, 414.
Lee, et al., Biochemistry, 1994, 33: 6024-6030.
Larhammar, Dan et al. Proc. Natl. Acad. Sci. USA (1983) 80: 7313-7317.
Gamper Howard B.
Kutyavin Igor V.
Lukhtanov Eugeny A.
Meyer, Jr. Rich B.
Epoch Pharmaceuticals, Inc.
Marschel Ardin H.
Riley Jezia
LandOfFree
Covalently linked oligonucleotide minor grove binder conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Covalently linked oligonucleotide minor grove binder conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Covalently linked oligonucleotide minor grove binder conjugates will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-270343