Attenuated microorganisms for the treatment of infection

Details Attenuated microorganisms for the treatment of infection Attenuated microorganisms for the treatment of infection

2007-05-01

2007-05-01

Navarro, Mark (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S093100, C435S252100

Reexamination Certificate

active

10822053

ABSTRACT:
The present invention pertains to aSalmonellamicroorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response. The present invention also pertains to vaccine compositions and methods for treating and preventing aSalmonellainfection in a patient.

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