Asymmetric synthesis

Details Asymmetric synthesis Asymmetric synthesis

1993-10-12

1994-11-08

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

568630, 568631, C07D33316, C07C 4105, C07C 4320

Patent

active

053628861

ABSTRACT:
This invention provides a stereospecific process for the synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a key intermediate in the synthesis of duloxetine.

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CA 116(1): 105979t, Nishikubo et al., "Solvent and Catalyst Effects On Addition Reaction of Phenyl Glycidyl Ether With S-Phenyl Thiocetate," Nippon Kagaku Kaishi 1991, (11), 1506-1513.
Deeter, et al., Tetrahedron Letters, 31(49), 7101-7104 (1990).
Wong, et al., Life Sciences, 43, 2049-2057 (1988).
Reinheimer, et al., J. Am. Chem. Soc., 83, 2873-2877 (1961).
Reinheimer, et al., J. Chem. Soc., 80, 164-168 (1958).

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