Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-09-12
1998-10-27
Ketter, James
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 76, G01N 3353, C12Q 168
Patent
active
058276556
ABSTRACT:
This disclosure relates to the n K.sup.+ channel expression product of the MK3 gene or a functionally bioactive equivalent thereof and its uses, particulary in combination with identifying immune responses and materials modulating or blocking same.
REFERENCES:
Sands, et al. 1989. J. Gen. Physiol. vol. 93 pp. 1061-1074.
MacKinnon, et al. 1989. Science vol. 245, pp. 1382-1385.
Till, M.A., et al., "HIV-infected cells are killed by rCD4-ricia A chain", Biological Abstracts, 87(4):AB-167 (No. 34914) (1989).
Katz, F.E., et al., "Elimination of T cells from human peripheral blood and bone marrow using a cocktail of three and T-cell immunotoxins", Biological Abstracts, 85(7):AB-651 (No. 69872) (1988).
Theofilopoulos, A.N., et al., "Murine Models of Systemic Lupus Erythematosus", Advance Immunology, 47:269-390 (1985).
Shapiro, M.S., et al., "Two Types of Potassium Channels in a Lymphoma Cell Line", Biophysical Journal, 53:550a (1988).
Lewis, R.S., et al., "Subset-Specific Expression of Potassium Channels in Developing Murine T Lymphocytes", Science, 239:771-775 (1988).
DeCoursey, T.E., et al., "Mitogen Induction of Ion Channels in Murine T Lymphocytes", The Journal of General Physiology, 89;405-420 (1987).
Chandy, K.G, et al., "Altered K.sup.+ Channel Expression in Abnormal T Lymphocytes from Mice with the lpr Gene Mutation", Science, 233:1197-1200 (1986).
Grissmer, S., et al., "Abundant Expression of Type 1 K.sup.+ Channels, A Marker for Lymphoproliferative Diseases?", The Journal of Immunology, 141(4): 1137-1142 (1988).
DeCoursey, T.E., et al., "Voltage-gated K.sup.+ channels in human T lymphocytes: a role in mitogenesis?", Nature, 307 (5950):465-468 (1984).
Wofsy, D., et al., "Successful Treatment or Autoimmunity in NZB/NZW F.sub.1 Mice with Monoclonal Antibody to L3T4", Journal of Experimental Medicine, 161:378-391 (1985).
Wofsy, D., et al., "Treatment of Murine Lupus with Monoclonal Anti-T Cell Antibody", The Journal of Immunology,134(2):852-857 (1985).
Santoro, T.J. et al., "The Contribution of L3T4.sup.+ T Cells to Lymphoproliferation and Autoantibody Production in MRL-lpr/lpr Mice", J. Exp. Med., 167:1713-1718 (1988).
Waldor, M.K., et al., "Reversal of Experimental Allergic Encephalomyelitis with Monoclonal Antibody to a T-Cell Subset Marker", Science, 227:415-417 (1985).
Ranges, G.E., et al., "Prevention of Type II Collagen-Induced Arthritis by In Vivo Treatment with Anti-L3T4", J. Exp. Med., 162:1105-1110 (1985).
Christadoss, P., et al., "Immunotherapy for Myasthenia Gravis: A Murine Model", The Journal of Immunology, 136(7):2437-2440 (1986).
Wofsy, D., "Administration of Monoclonal Anti-T Cell Antibodies Retards Murine Lupus in BXSB Mice", The Journal of Immunology, 136(12):4554-4560 (1986).
Sainis, K., et al., "CD4.sup.+ Cell Lines with Selective Patterns of Autoreactivity as well as CD4.sup.- CD8.sup.- T Helper Cell Lines Augment the Production of Idiotypes Shared by Pathogenic Anti-DBA Autoantibodies in the NZB X SWR Model of Lupus Nephritis", The Journal of Immunology, 140(7):2215-2224 (1988).
Shivakumar, S., et al., "Unusual T Helper Cells in Humans Augment the Production of Pathogenic Anti-DNA Autoantibodies", FASEB J., 3:A492 (No. 1548) (1989).
Datta, S.K., et al., "Inductiion of a Cationic Shift in IgG Anti-DNA Autoantibodies", J. Exp. Med., 165:1252-1268 (1987).
Miller, B.J., et al., "Both the LYT-2.sup.+ and L3T4.sup.+ T Cell Subsets are Required for the Transfer of Diabetes in Nonobese Diabetic Mice", The Journal of Immunology, 140(1):52-58 (1988).
Koike, et al., "Preventive Effect of Monoclonal Anti-L3T4 Antibody on Development of Diabetes in NOD Mice", Diabetes,36:539-541 (1987).
Tempel, B.L., et al., "Cloning of a probable potassium channel gene from mouse brain", Nature,332:837-839 (1988).
Baumann, A., et al., "Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systems", The EMBO Journal, 7(8):2457-2463 (1988).
McKinnon, D., "Isolation of a cDNA Clone Coding for a Putative Second Potassium Channel Indicates the Existence of a Gene Family", The Journal of Biological Chemistry, 264(14):8230-8236 (1989).
Frech, G.C., et al., "A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning", Nature, 340:642-645 (1989).
McCormack, T., et al., "Molecular cloning of a member of a third class of Shaker-family K.sup.+ channel genes in mammals", Proc. Natl. Acad. Sci. USA, 87:5227-5231 (1990).
Ribera, A.B., "A Potassium Channel Gene is Expressed at Neural Induction", Neuron, 5:691-701 (1990).
Chandy, K.G., et al., "The Shaw-Related Ky3.1 Gene on Human Chromosome 11 Encodes the 1-Type K.sup.+ Channel in T Cells", Biophysical Journal, 61(2):A257 (1484) (1992).
Grissmer, S., et al., "Expression and chromosomal localization of a lymphocyte K.sup.+ channel gene", Proc. Natl. Acad. Sci. USA, 87:9411-9415 (1990).
Luneau, C.J., et al., "Alternative splicing contributes to K.sup.+ channel diversity in the mammalian central nervous system", Proc. Natl. Acadi. Sci. USA, 88;3932-3936 (1991).
Murakami, M., et al., "In Vivo Effects of Tetraethylammonium (TEA), A K.sup.+ Channel Blocker in MRL/lpr Mice", The FASEB Journal, p. A2108 (No. 2404) (1990).
Chandy, K.G., et al., "Altered K.sup.+ Channel Expression in T Cells: A Molecular Feature Unique to Murine SLE and Type-1 Diabetes", American Rheumatism Association, 53rd Annual Scientific Meeting, Cincinnati, Ohio (1989).
Chandy, K.G., et al., "The MBK1 mouse K.sup.+ channel protein is encoded by a single uninterrupted exon", Society for Neuroscience Abs., vol. 15 (No. 230.1) (1989).
Grissmer, S., et al., "CD4.sup.- CD8.sup.- T Cells from Mice with Collagen Arthritis Display Aberrant Expression of Type 1 K.sup.+ Channels", The Journal of Immunology, 145(7):2105-2109 (1990).
Mathew, M.K., et al., "Cloning and characterization of human potassium channel genes", Society for Neuroscience Abstracts, 15(1):540 (No. 220.12) (1989).
Ramaswami, M., et al., "Human Potassium Channel Genes: Molecular Cloning and Functional Expression", Molecular and Cellular Neurosciences, 1:214-223 (1990).
Yokoyama, S., et al., "Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells, Primary structure and function expression from cDNAs", FEBS Letters, 259(1):37-42 (1989).
Grupe, A., et al., "Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family", The EMBO Journal, 9(6):1749-1756 (1990).
Chandy, K.G., et al., "A Family of Three Mouse Potassium Channel Genes with Intronless Coding Regions", Science, 247:973-975 (1990).
Chandy, K.G., et al., "Multiple Genes Contribute to K.sup.+ Channel Diversity in the Mouse KG", Abtract Submission, Baltimore.
Grissmer, S., et al., "Does the MK3 Gene Encode the Voltage-Gated Type n K.sup.+ Channel in T Lymphocytes?", International Biophysical Congress, Vancouver, Canada (1990).
Douglass, J., et al., "Characterization and Functional Expression of a Rat Genomic DNA Clone Encoding a Lymphocyte Potassium Channel", The Journal of Immunology, 144(12):4841-4850 (1990).
Stuhmer, W., et al., "Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain", The EMBO Journal, 8(11):3235-3244 (1989).
Swanson, R., et al., "Total Synthesis, Expression, and Functional Assay of a Gene Encoding a Human Delayed Rectifier Potassium Channel", Biophysical Journal, 57:211a (1990).
Miller, R.J., "Glucose-regulated potassium channels are sweet news for neurobiologists", Trends in Neuroscience, 13(6):197-199 (1990).
Cook, N.S., "The pharmacology of potassium channels and their therapeutic potential", TIPS, 9:21-28 (1988).
Robertson, D.W., et al., "Potassium Channel Modulators: Scientific Applications and Therapeutic Promise", Journal of Medical Chemistry, 33(6):1529-1541 (1990).
Swanson, R., et al., "Cloning and Expression of cDNA and Genomic Clones Encoding Three Delayed Rectifier Potassium Channels in Rat Brain", Neuron, 4:929-939 (1990).
Chandy, K.G., et al., "Autoimmune diseases linked to abnormal K.sup.+ channel expression in double-negat
Cahalan Michael D.
Chandy Kanianthara G.
Dethlefs Brent A.
Goldin Alan L.
Grissmer Stephan
Dreger Walter H.
Ketter James
Kresnak Mark T.
The Regents of the University of California
Yucel Irem
LandOfFree
Assay, methods and products based on n K.sup.+ channel expressi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Assay, methods and products based on n K.sup.+ channel expressi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assay, methods and products based on n K.sup.+ channel expressi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1612790