Assay for an antifreeze protein

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 74, 435 14, C12Q 154

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059288779

ABSTRACT:
Yeast is genetically engineered by transformation with an expression vector containing a natural yeast secretion signal sequence combined appropriately with a chemically synthesized gene encoding antifreeze protein resulting in the expression, proper processing, and secretion of antifreeze protein which is heterologous to yeast in recoverable amounts. Disclosed are DNA sequences comprising structural genes encoding peptides having amino acid sequences with the biochemical or physiochemical properties of antifreeze protein and a method of combining the antifreeze protein gene sequences with appropriate expression vectors.

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Brake et al. (1984) PNAS vol. 81 4642-4646.
Britz (1987) Austrail. J Biotech 1(3), 29-40.
Ginsberg et al (1979) J. Clin. Endocrin Metab. 48(1),43-49.
Scopes (1982) "Protein Purification", p. 183 Springer/Verlag, N.Y.
Gronlic et al J Biol. Chem. 259:14960 (1984).
Pesole et al. Nuc Acid Res vol. 16: 1715 (1988).
Davies et al. PNAS 79: 335 (1982).
Groulie et al. (1984) J. BIol. Chem. 259:14960.
Pesole et al. (1988) Nuc Acid Res:1715.
Davies et al. (1982) PNAS 79:335.

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