Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-09-30
1999-08-31
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514252, 5142358, 514307, 514341, 514362, 514369, 514397, 514398, 514400, 514409, 514418, 544 6, 544133, 544165, 544357, 544360, 544363, 544370, 546210, 5462784, 548134, 548214, 5483154, 5483235, 54832401, 5483405, 548550, 548517, A61K 41315, A61K 3143, A61K 3147, A61K 3144, A61K 3141, A61K 31425, A61K 31415, A61K 3140
Patent
active
059454130
ABSTRACT:
This invention relates to a novel class of compounds that are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting aspartyl protease activity and methods for treating viral infections using the compounds and compositions of this invention.
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Marquez et al, J. Org. Chem., vol. 37, No. 16, pp 2558 to 2561 (1972).
Baker Christopher Todd
Bhisetti Govinda Rao
Deininger David D.
Salituro Francesco Gerald
Spaltenstein Andrew
Govindaswamy N.
Haley, Jr. James F.
Higel Floyd D.
Vertex Pharmaceuticals Incorporated
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